DECPA - Departamento de Clínicas Pediátrica e do Adulto

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/8505

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2016 - 20192

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Autor: search.filters.author.Pimenta, Fausto Aloísio PedrosaAssunto: search.filters.subject.Triglycerides

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    Effects of vitamin D supplementation on cardiovascular risk factors in shift workers : study protocol for randomized, double-blind, placebo-controlled clinical trial.
    (2019) Fajardo, Virgínia Capistrano; Oliveira, Fernando Luiz Pereira de; Coelho, George Luiz Lins Machado; Pimenta, Fausto Aloísio Pedrosa; Freitas, Silvia Nascimento de; Ribeiro, Antônio Luiz Pinho; Soares, Maria Marta Sarquis; Lauria, Márcio Weissheimer; Farias, Rosielle da Costa; França, Ive Bahia; Nascimento Neto, Raimundo Marques do
    Objective: The present clinical study aims to describe protocol to evaluate the effects of vitamin D3 supplementation on the cardiovascular risk factors in a population of rotating shift workers. Design: A randomized, double-blind, placebo-controlled, parallel group clinical trial testing 2 oral dosages of cholecalciferol (14,000 IU and 28,000 IU per week) for 12 months. Setting: The primary outcome for evaluation is an 18% reduction in hypertriglyceridemia (≥150mg/dL) between pre and postintervention measurements. Baseline characteristics of the study population will be summarized separately within each randomized group, and will use tests for continuous and categorical variables. For all tests, a P<.05 will be considered significant. The analysis of primary and secondary outcomes will use an intention-to-treat population and a per-protocol population. The primary and secondary outcomes will be compared separately between each treatment group and placebo, using binary logistic regression or regressão de Poisson for proportions (for binary outcomes) and using linear regression for differences in means (for continuous endpoints), with 95% confidence intervals. Participants: Rotating shift workers, adults aged between 18 and 60 years, with hypovitaminosis D and alterations in at least 1 of the following parameters: fasting glucose, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, blood pressure, and waist circumference. Conclusion: This clinical trial aims to contribute to the gap in knowledge about the potential, dose, and time of vitamin D supplementation to generate beneficial effects on triglycerides in a population at increased risk for hypertriglyceridemia and vitamin D deficiency. Abbreviations: 25(OH)D = vitamin D, AUDIT = Alcohol Use Disorders Identification Test, BAI = body adiposity index, BMI = body mass index, C index = conicity index, CI = confidence interval, DMC = data monitoring committee, HDL = high-density lipoprotein, HOMA-IR = homeostatic model for insulin resistance, IPAQ = International Physical Activity Questionnaire, ITT = intention-to-treat, LDL = low-density lipoprotein, MMSE = Mini Mental State Examination, PP = per-protocol, PTH = parathyroid hormone, RR = relative risk, SF-36 = The Medical Outcomes Study 36-Item Short-Form Health Survey, TSC = Trial Steering Committee, WHOQOL = World Health Organization Quality Of Life Instrument, WHR = waist–hip ratio, WHtR = waist–height ratio.
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    Hypovitaminosis D is associated with visceral adiposity, high levels of low-density lipoprotein and triglycerides in alternating shift workers.
    (2016) Batista, Aline Priscila; Ambrosim, Ticiana Vazzoler; Nascimento Neto, Raimundo Marques do; Pimenta, Fausto Aloísio Pedrosa; Freitas, Silvia Nascimento de; Lauria, Márcio Weissheimer; Coelho, George Luiz Lins Machado
    Background: Studies suggest that there is a strong association between low vitamin D levels and cardiovascular disease (CVD) and its risk factors (RFs). Hypovitaminosis D (25(OH)D < 30 ng/mL or 75 nmol/L) is a recent public health problem that has reached different populations. The objective of the study was to investigate whether hypovitaminosis D is an additional mechanism to explain the disturbances in the lipid profile as well as the excess of abdominal fat presented by alternating shift workers of a mining company in the region of Inconfidentes, Minas Gerais, Brazil. Methods: A cross-sectional study was conducted in a sample of 391 adult males, aged 20 - 57 years old and working alternating shifts, who had at least one risk criterion for CVD. Demographic, behavioral, clinical, and anthropometric and body composition variables were obtained. A blood sample was drawn for determining 25(OH) D, parathyroid hormone intact molecule, lipid profile, blood glucose, insulin, C-reactive protein, and adipokines. Results: The average age of the 391 study participants was 36.1 ± 7.3 years. The percentage of hypovitaminosis D and dyslipidemia was 73% and 74.2%, respectively. Excess visceral fat was significant in the hypovitaminosis D group, with an odds ratio (OR) of 2.4 (95% confidence interval (CI): 1.1 - 5.2). Dyslipidemia showed 25(OH)D levels significantly lower (OR: 2.7, 95% CI: 1.6 - 4.3) than in individuals with normal levels of cholesterol and fractions, and triglycerides. After adjusted the analysis by age and seasonality, the vitamin levels had a significant inverse association and dose-dependent with lowdensity lipoprotein (OR: 5.9), triglycerides (OR: 2.3) and visceral fat area (OR: 2.4). Conclusion: Hypovitaminosis D and dyslipidemia were found in the majority of our mining company shift workers. Furthermore, excess visceral adiposity, hypertriglyceridemia and high low-density lipoprotein cholesterol levels are strong predictors of hypovitaminosis D.