Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.
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2023
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Background: SARS-CoV-2 virus originated in Wuhan (China) in December (2019) and quickly spread worldwide. Antigen tests are rapid
diagnostic tests (RDT) that produce results in 15-30 min and are an important tool for the scale-up of COVID-19 testing. COVID-19
diagnostic tests are authorized for self-testing at home in some countries, including Brazil. Widespread COVID-19 diagnostic testing is
required to guide public health policies and control the speed of transmission and economic recovery.
Methods: Patients with suspected COVID-19 were recruited at the Hospital da Baleia (Belo Horizonte, Brazil). The SARS-CoV-2 antigen-
detecting rapid diagnostic tests were evaluated from June 2020 to June 2021 using saliva, nasal, and nasopharyngeal swab samples from
609 patients. Patient samples were simultaneously tested using a molecular assay (RT-qPCR). Sensitivity, specificity, accuracy, and positive
and negative predictive values were determined using the statistical program, MedCalc, and GraphPad Prism 8.0.
Results: The antigen-detecting rapid diagnostic tests displayed 98% specificity, 60% sensitivity, 96% positive predictive value, and
moderate concordance with RT-qPCR. Substantial agreement was found between the two methods for patients tested < 7 days of
symptom onset.
Conclusions: Our findings support the use of Ag-RDT as a valuable and safe diagnostic method. Ag-RDT was also demonstrated to be an
important triage tool for suspected COVID-19 patients in emergencies. Overall, Ag-RDT is an effective strategy for reducing the spread of
SARS-CoV-2 and contributing to COVID-19 control.
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Covid-19, Rapid test, Self-test
Citação
FILGUEIRAS, P. S. et al. Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device. Revista da Sociedade Brasileira de Medicina Tropical, v. 56, artigo e0167, 2023. Disponível em: <https://www.scielo.br/j/rsbmt/a/TyFVt3tgWVdztfdrRXKyykG/>. Acesso em: 01 ago. 2023.