Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.
dc.contributor.author | Corrêa, Paulo Roberto Ceridóreo | |
dc.contributor.author | Miranda, Roqueline Rodrigues Silva de | |
dc.contributor.author | Duarte, Lucienir Pains | |
dc.contributor.author | Silva, Grácia Divina de Fátima | |
dc.contributor.author | Vieira Filho, Sidney Augusto | |
dc.contributor.author | Okuma, Adriana Akemi | |
dc.contributor.author | Carazza, Fernando | |
dc.contributor.author | Díaz, José Andrés Morgado | |
dc.contributor.author | Pinge Filho, Phileno | |
dc.contributor.author | Yamauchi, Lucy Megumi | |
dc.contributor.author | Nakamura, Celso Vataru | |
dc.contributor.author | Ogatta, Sueli Fumie Yamada | |
dc.date.accessioned | 2017-03-31T12:04:25Z | |
dc.date.available | 2017-03-31T12:04:25Z | |
dc.date.issued | 2012 | |
dc.description.abstract | We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections. | pt_BR |
dc.identifier.citation | CORRÊA, P. R. C. et al. Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. Pathogens and Global Health, v. 106, p. 107, 2012. Disponível em: <http://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002>. Acesso em: 20 jan. 2017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1179/2047773212Y.0000000002 | |
dc.identifier.issn | 2047-7732 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/7506 | |
dc.identifier.uri2 | http://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.title | Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |