Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.
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2012
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We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl-
39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on
the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an
antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl
benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against
epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and
the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal
macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected
cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective
and safer chemotherapeutic agents against T. cruzi infections.
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CORRÊA, P. R. C. et al. Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi. Pathogens and Global Health, v. 106, p. 107, 2012. Disponível em: <http://www.tandfonline.com/doi/full/10.1179/2047773212Y.0000000002>. Acesso em: 20 jan. 2017.