Factors associated with short and long term cognitive changes in patients with sepsis.
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2018
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This study aimed to assess cognition in patients with severe sepsis or septic shock and whether
cognitive impairment was associated with clinical and laboratory parameters. We conducted a
cohort study of patients with severe sepsis and septic shock evaluated within 24 h and one year
after ICU discharge. Demographic, clinical and laboratory data were analyzed, and the following
neuropsychological tests were applied: Consortium to Establish Registry for Alzheimer’s Disease, Mini-
Mental State Examination, and Trail Making Test forms A and B. We included 33 patients, mean age
of 49, 19% were female. Patients underperformed on most measures 24 h after ICU discharge, with
improvement on follow-up. IQCODE, APACHE II scores, NSE and IFN-γ levels at ICU discharge were
associated with poor cognitive performance, while higher educational level was associated with good
cognitive performance. The time to first antibiotic dose, accumulated dose of haloperidol during UCI
stay and mean glycemia were also associated with poor cognitive outcome. In general, patients with
severe sepsis or septic shock have cognitive impairment that can improve over time. This improvement
was associated with factors identified during their ICU stay, such as cognitive reserve, educational level,
mean glycemia during ICU stay and NSE level.
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CALSAVARA, A. J. C. et al. Factors associated with short and long term cognitive changes in patients with Sepsis. Scientific Reports, v. 8, p. 1-10, 2018. Disponível em: <https://www.nature.com/articles/s41598-018-22754-3>. Acesso em: 05 abr. 2018.