DEFAR - Departamento de Farmácia

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/530

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2021 - 20222

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Assunto: search.filters.subject.SARS-CoV-2

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    Immunogenicity, effectiveness, and safety of inactivated virus (CoronaVac) vaccine in a two-dose primary protocol and BNT162b2 heterologous booster in Brazil (Immunita-001) : a one year period follow up phase 4 study.
    (2022) Grenfell, Rafaella Fortini Queiroz; Almeida, Nathalie Bonatti Franco; Filgueiras, Priscilla Soares; Corsini, Camila Amormino; Gomes, Sarah Vieira Contin; Miranda, Daniel Alvim Pena de; Lourenço, Adelina Junia; Martins Filho, Olindo Assis; Oliveira, Jaquelline Germano de; Carvalho, Andréa Teixeira de; Campos, Guilherme Rodrigues Fernandes; Nogueira, Maurício Lacerda; Alves, Pedro Augusto; Fernandes, Gabriel da Rocha; Castilho, Leda dos Reis; Lima, Túlio Macedo; Abreu, Daniel Paiva Barros de; Alvim, Renata Guimarães Ferreira; Silva, Thaís Bárbara de Souza; Jeremias, Wander de Jesus; Otta, Dayane Andriotti; Azevedo, Ana Carolina Campi; Immunita-001 Team
    Background: Effective and safe vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical to controlling the COVID-19 pandemic and will remain the most important tool in limiting the spread of the virus long after the pandemic is over. Methods: We bring pioneering contributions on the maintenance of the immune response over a year on a real-life basis study in 1,587 individuals (18-90 yrs, median 39 yrs; 1,208 female/379 male) who underwent vaccination with two doses of CoronaVac and BNT162b2 booster after 6-months of primary protocol. Findings: Elevated levels of anti-spike IgG antibodies were detected after CoronaVac vaccination, which significantly decreased after 80 days and remained stable until the introduction of the booster dose. Heterologous booster restored antibody titers up to-1·7- fold, changing overall seropositivity to 96%. Titers of neutralising antibodies to the Omicron variant were lower in all timepoints than those against Delta variant. Individuals presenting neutralising antibodies against Omicron also presented the highest titers against Delta and anti-Spike IgG. Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. A stronger interaction between those mediators was noted over time. Prior exposure to the virus leaded to a more robust cellular immune response and a rise in antibody levels 60 days post CoronaVac than in individuals with no previous COVID-19. Both vaccines were safe and well tolerated among individuals. Interpretation: Our data approach the effectiveness of CoronaVac association with BNT162b2 from the clinical and biological perspectives, aspects that have important implications for informing decisions about vaccine boosters. Funding: Fiocruz, Brazil.
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    COVID-19 in medium-sized municipalities in the 14 health macro-regions of Minas Gerais, Brazil.
    (2021) Paula Júnior, Waldemar de; Nascimento, Renata Cristina Rezende Macedo do; Matiles, R.S.; Lima Neto, Francisco Ferreira de; Leles, Michel C. R.; Guimarães, H. N.; Guimarães, Andrea Grabe
    The present study focused on the scenario of confirmed cases of SARS-CoV-2 infection in the state of Minas Gerais (MG), Brazil, from March 2020 to March 2021. We evaluated the evolution of COVID-19 prevalence and death in one municipality from each of the 14 health macro-regions of MG state. Socio-demographic characteristics and variables related to the municipalities were analyzed. The raw dataset used in this study was freely sourced from the website Brasil.io. From the raw dataset, two time series were extracted: the cumulative confirmed cases of COVID-19 and cumulative death counts, and they were compared to the state data using a nowcasting approach. In order to make time series comparisons possible, all data was normalized per 100,000 inhabitants. When analyzing in light of colored wave code interventions initiated in August 2020 in MG, for the majority of the municipalities, there was an absence of clear influence on prevalence and deaths. The national holidays in the first semester of 2020 had a small impact on the COVID-19 prevalence of the municipalities, but the holidays in the second semester of 2020 and beginning of 2021 caused important impacts on COVID-19 prevalence. The low number of ICU beds in some municipalities contributed to the higher number of deaths. The analysis showed here is expected to contribute to the improvement of decision making of the MG government, as it opened a huge possibility to have the total macro-regions and state data analyzed.