DEALI - Departamento de Alimentos
URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/540
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Item Effect of dietary chitin on cholesterol absorption and metabolism in rats.(1992) Zacour, Albertina C.; Silva, Marcelo Eustáquio; Cecon, Paulo Roberto; Bambirra, Eduardo Alves; Vieira, Enio CarlosThe effect of chitin at the level of 5% in the diet on cholesterol absorption and metabolism was studied in Wistar rats fed on diet containing beef tallow (7%) and cholesterol (1%). When compared with pair-fed controls, rats fed on diet containing chitin had: (1) similar weight gain and feed efficiency, (2) lower apparent protein digestibility, (3) equivalent liver steatosis, (4) reduced levels of liver triglycerides and cholesterol, (5) similar levels of serum and fecal cholesterol, (6) higher excretion of triglycerides in feces.Item The effect of chronic ingestion of ethanol on modulation of granulomatous inflammation in experimental schistosomiasis in mice.(1993) Castro, Lúcia Porto Fonseca de; Bambirra, Eduardo Alves; Coelho, Paulo Marcos Zech; Silva, Marcelo EustáquioWe studied the role of ethanol on the modulation of liver granulomata around Schistosoma mansoni eggs in mice. Albino mice, receiving 7% ethanol as the sole drinking liquid, at 60 and 90 days post-infection, presented smaller granulomata than controls did, when sacrificed at 120 days post-infection. No differences in diameters could observed, when ethanol was given 4 months before up to 120 days after infection. The results suggested that modulation of schistosomose granulomata by ethanol ingestion varies with time and duration of drug consumption.Item The effect of iron nutritional status on Trypanosoma cruzi infection in germfree and conventional mice.(1993) Pedrosa, Maria Lúcia; Nicoli, Jacques Robert; Silva, Marcelo Eustáquio; Silva, Marcio Eustáquio; Silva, Marcílio Eustáquio de Castro; Vieira, Leda Quercia; Bambirra, Eduardo Alves; Vieira, Enio Carlos1. Conventional (CV) and gnotobiotic (GN) female CFW mice were infected with the Y strain of Trypanosoma cruzi. 2. After infection, both CV and GN groups received injections of iron-dextran or desferrioxamine. Non-injected mice served as controls. 3. The parasitemia was more intense in iron-dextran-treated mice. 4. The iron levels in serum, liver, and spleen were: (a) not decreased by desferrioxamine and (b) increased by iron-dextran treatments. 5. An increase in leukocyte numbers was observed in all GN and CV groups after infection. 6. There was no difference in total iron binding capacity (TIBC) and iron saturation transferrin (IST) between GN and CV mice before infection. 7. In CV groups, after infection, TIBC was decreased whereas the levels of IST were increased; in GN the opposite occurred. 8. Trypanosome-specific IgG and IgM antibody levels were raised in the GN group but not in the CV group.Item Vitamin D overload and experimental Trypanosoma cruzi infection : parasitological and histopathological aspects.(1993) Silva, Marcelo Eustáquio; Silva, Marcílio Eustáquio de Castro; Nicoli, Jacques Robert; Bambirra, Eduardo Alves; Vieira, Enio Carlosl. Six groups of 45-day-old, 23.0 & 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LDm was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.