DEALI - Departamento de Alimentos

URI permanente desta comunidadehttp://www.hml.repositorio.ufop.br/handle/123456789/540

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Açaí (Euterpe oleracea Martius) promotes jejunal tissue regeneration by enhancing antioxidant response in 5-Fluorouracil-Induced mucositis.
(2020) Magalhães, Talita Alves Faria Martins; Souza, Melina Oliveira de; Gomes, Sttefany Viana; Silva, Raiana Mendes e; Martins, Flaviano dos Santos; Freitas, Renata Nascimento de; Amaral, Joana Ferreira do
Intestinal mucositis (IM) caused by antineoplastic chemotherapy is characterized by an important inflammatory process, which may compromise ongoing treatment. Our study aimed to investigate the effect of Ac¸aı (Euterpe oleracea Martius) on the antioxidant response in BALB/c mice pretreated with Ac¸aı pulp (200 g/kg) for 14 day. A group of animals receiving a single intraperitoneal injection of 5-FU (200 mg/kg) were euthanized on day three (D3) or seven (D7) after administration, the distal jejunum was isolated for the analyses of histology, superoxide dismutase (SOD) and catalase (CAT) enzyme activities, and concentration of total sulfhydryl groups (GSH). Seven days after induction, the intake of Ac¸aı by the IM group almost completely regenerated tissue histology. Notably, SOD activity decreased in the MUC þ Ac¸aı group (D3). CAT activity reduced on D3 and D7 in the IM groups and Ac¸aı treatment groups, respectively. No change was observed in the total GSH concentration at the tissue level. Our results demonstrated the protective effect of Ac¸aı pulp components on intestinal damage induced by 5-FU, as well as the ability to control the response to oxidative stress, in order to mobilize defense pathways and promote tissue repair.
A prospective study in women : açaí (Euterpe oleracea Martius) dietary intake affects serum p-selectin, leptin, and visfatin levels.
(2021) Souza, Melina Oliveira de; Barbosa, Priscila Oliveira; Pala, Daniela; Amaral, Joana Ferreira do; Volp, Ana Carolina Pinheiro; Freitas, Renata Nascimento de
Background: açaí is the fruit of the palm tree Euterpe oleracea Martius, which is native to the Amazon region. This fruit has been extensively studied due to its potential effects on human health. Studies have also evaluated the potential effect of açaí on the inflammatory response, but there are still few studies that have assessed this property in humans. Objective: in this study we aimed to evaluate the effects of 200 g of açaí pulp consumption per day during four weeks on a rich panel of inflammatory biomarkers. Methods: a prospective nutritional intervention study was conducted on forty apparently healthy women who consumed 200 g of açaí pulp per day for four weeks. A panel of serum inflammatory markers were evaluated before and after the nutritional intervention, namely, cell adhesion molecules (ICAM-1, IVAM-1, P-selectin, MCP-1, and fractalkine), interleukins (IL-1β, IL-6, IL-8, IL-10, and IL-17) and adipokines (adiponectin, leptin, visfatin, and adipsin). The data were analyzed using paired Student’s t-test to evaluate the effect of the intervention using PASW Statistics, version 18.0, and a p-value of < 0.05 was considered significant. Results: four weeks of açaí pulp consumption decreased p-selectin, leptin, and visfatin concentrations in the serum of the participating women. Conclusion: these results show that consumption of açaí pulp was able to modulate important biomarkers of the inflammatory process in apparently healthy women.