Navegando por Autor "Vieira, Érica Leandro Marciano"
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Item 10 km running race induces an elevation in the plasma myokine level of nonprofessional runners.(2019) Barbosa, Lucas Soares Marcucci; Martins Junior, Francisco de Assis Dias; Lobo, Lázaro Fernandes; Morais, Mariana Gomes de; Moreira, Janaina Matos; Vieira, Érica Leandro Marciano; Silva, Albená NunesPurpose Acute and chronic physical exercise is believed to have benefcial efects on human health. Exercise is also able to modulate immune function. We hypothesed that exercise is able to induce many benefts for human health by modulating immune functions through the production and release of many myokines. Here, we investigated the efects of a running race on the level of plasmatic myokines. Methods Nine male volunteers took part in this study. Blood samples were obtained before, immediately after and 24 h after the race. Results Participants completed the 10 km running race in 49.85±7.04 min. The levels of IL-6 elevated after exercise (0.94±0.4–2.82±0.3 pg/ml). The IL-15 plasma level was also higher immediately after (0.88±0.25–1.29±0.36 pg/ml), and 24 h after (1.30±1.01 pg/ml), the end of the exercise. Irisin increased only 24 h after exercise (632.60±188.40– 974.70±232.30 pg/ml). FABP3 increased after exercise (829.60±68.93–1306.00±319.10 pg/ml). The plasma levels of BDNF (4719.00±701.80–5557.00±810.30 pg/ml) and Fractalkine increased after exercise (101.2±34.96–134.90±43.62 pg/ ml). The level of FSTL (7265.00±1553.00–9074.00±1662.00 pg/ml) and Osteonectin (16.52±3.54–15.71±3.38 pg/ml) also increased after exercise, and then returned to baseline level 24 h after the end of the session. Conclusion Taken together, these results suggest that a 10 km running race induces elevation of important myokine plasma levels.Item Acute and chronic effects of strength training on plasma levels of adipokines in man.(2023) Barroso, Lucélia Scarabeli Silva; Faria, Marcelo Henrique Salviano de; Gomes, Antonio Felipe Souza; Barros, João Luís Vieira Monteiro; Kakehasi, Adriana Maria; Vieira, Érica Leandro Marciano; Silva, Ana Cristina Simões e; Silva, Albená Nunes daAdipose tissue is specialized cells that produce and release adipokines. Exercise may modulate adipokine production in adipocytes. The aim of this longitudinal study was to evaluate the acute and chronic effects of strength training (ST) on plas- ma levels of adiponectin, leptin, and resistin. Twelve untrained young male participants (23.42 ± 2.67 years) were selected. The training protocol consisted of 3 exercises, with 3 sets of 65% of 1RM (one-repetition maximum) with pause of 90 s be- tween sets with duration of 5 s/repetition (2 s conc/3 s ecc), 3 times a week for 10 weeks. Blood was collected at four time points: before and after the first ST session and before and after the last ST session. The comparisons between adipokine levels before and after the same training session showed acute changes, while the comparisons between levels before or after the first session versus before or after the last session revealed chronic alterations. ST increased adiponectin levels after the first exercise session in comparison to levels before this session [50 952 (46 568–51 894) pg/mL vs. 52 981 (49 901–54 467) pg/mL, p = 0.019]. Similar differences were observed for resis- tin levels, which were higher after the last session compared to before [4 214.4 ( ± 829) pg/mL vs. pre-S30 2 251.3 ( ± 462.2) pg/mL, p = 0.0008] and in the comparison between after the last and after the first ST sessions [4 214.4 ( ± 829.0) pg/mL vs. 1 563.7 ( ± 284.8) pg/mL, p = 0.004]. Leptin levels acutely changed in the last training session. ST produced acute and chronic changes in plasma adipokines.Item Mechanisms underlying fat pad remodeling induced by fasting : role of PAF receptor.(2019) Lacerda, Débora Romualdo; Soares, Danusa Dias; Costa, Kátia Anunciação; Silva, Albená Nunes da; Rodrigues, Débora Fernandes; Sabino, Josiana Lopes; Silveira, Ana Letícia Malheiros; Pinho, Vanessa; Vieira, Érica Leandro Marciano; Menezes, Gustavo Batista; Antunes, Maísa Mota; Teixeira, Mauro Martins; Ferreira, Adaliene Versiani MatosObjectives: Fasting has long been practiced for political and religious reasons and to lose weight. However, biological responses during fasting have yet to be fully understood. Previous studies have shown that cytokines may control fat pad expansion, at least in part, owing to the induction of lipolysis. Indeed, we have previously shown that mice with a lower inflammatory response, such as platelet-activating factor receptor knockout mice (PAFR / ), are prone to gain weight and adiposity. The aims of this study were to determine whether adipose tissue becomes inflamed after fasting and to evaluate whether the PAF signaling is a fator in the fat loss induced by fasting. Methods: Wild-type (WT) and PAFR / mice were fasted for 24 h. Adiposity, leukocyte recruitment, and cytokine levels were evaluated. Multiple comparisons were performed using two-way analysis of variance and post hoc Fisher exact test. Results: After fasting, male WT mice showed lower adiposity (P < 0.001), higher recruitment of immune cells (P < 0.001), and increased cytokine levels (P < 0.05) in adipose tissue. Although WT mice lost ~79% of their adipose tissue mass, PAFR / mice lost only 36%. Additionally, PAFR / mice did not show enhanced cytokine and chemokine levels after fasting (P > 0.05). Conclusion: Despite low-grade inflammation being associated with metabolic syndrome, at least in part, the inflammatory milieu is also important to induce proper fat mobilization and remodeling of adipose tissue.Item Soluble tumor necrosis factor receptors are associated with severity of kidney dysfunction in pediatric chronic kidney disease.(2019) Moreira, Janaina Matos; Silva, Albená Nunes da; Vieira, Érica Leandro Marciano; Teixeira Junior, Antonio Lucio; Kummer, Arthur Melo e; Silva, Ana Cristina Simões eBackground In adult chronic kidney disease (CKD) patients, there is a positive association between inflammation and progressive renal dysfunction. Higher levels of soluble receptors of tumor necrosis factor (sTNFR) have been related to worst prognosis of adult CKD patients. Therefore, the present study aimed to evaluate soluble TNF receptors in children and adolescents with CKD and to search for an association with clinical and laboratory features. Methods Demographic, clinical, anthropometric, and laboratory data were evaluated in 34 pediatric patients with CKD and in 34 healthy sex- and age-matched controls. Blood samples were collected in both groups to measure sTNFR by enzyme-linked immunosorbent assay. The modified Schwartz formula was used to estimate glomerular filtration rate (GFR). Results Pediatric patients with CKD had significantly higher plasma concentrations of soluble TNF receptors types 1 and 2 (sTNFR1 and sTNFR2) in comparison to sex- and age-matched healthy controls. Plasma levels of sTNFR1 and sTNFR2 increased progressively as renal function worsened, being inversely and significantly correlated with GFR (r = − 0.853 for sTNFR1 and GFR, r = − 0.729 for sTNFR2 and GFR). Conclusions Children and adolescents with CKD exhibited higher plasma levels of sTNFR1 and sTNFR2 than healthy controls, which increased in relation to renal function deterioration. Plasma levels of sTNFR1 and sTNFR2 emerge as markers of progressive CKD in pediatric patients.Item Strength training session induces important changes on physiological, immunological, and inflammatory biomarkers.(2018) Fortunato, Ayla Karine; Pontes, Washington Martins; Souza, Débora Maria Soares de; Prazeres, Jéssica Santos Ferreira; Barbosa, Lucas Soares Marcucci; Santos, Júlia Miranda Mól; Vieira, Érica Leandro Marciano; Bearzoti, Eduardo; Pinto, Kelerson Mauro de Castro; Silva, André Talvani Pedrosa da; Silva, Albená Nunes daStrength exercise is a strategy applied in sports and physical training processes. It may induce skeletal muscle hypertrophy. The hypertrophy is dependent on the eccentric muscle actions and on the inflammatory response. Here, we evaluate the physiological, immunological, and inflammatory responses induced by a session of strength training with a focus on predominance of the eccentric muscle actions. Twenty volunteers were separated into two groups: the untrained group (UTG) and the trained group (TG). Both groups hold 4 sets of leg press, knee extensor, and leg curl at 65% of personal one-repetition maximum (1RM), 90 s of recovery, and 2conc/3eccen of duration of execution in each repetition. Blood samples were collected immediately before and after, 2 hours after, and 24 h after the end of the exercise session. The single session of strength training elevated the heart rate (HR), rating of perceived exertion (RPE), visual analog scale (VAS), and lactate blood level in UTG and TG. Creatine kinase (CK) levels were higher at 2 and 24 h after the end of the exercise in UTG and, in TG, only at 24 h. The number of white blood cells (WBC) and neutrophils increased in UTG and TG, post and 2 h after exercise. Lymphocytes increased postexercise but reduced 2 h after exercise in both groups, while the number of monocytes increased only immediately after the exercise session in UTG and TG. The strength training session elevated the levels of apelin and fatty acid-binding proteins-3 (FABP3) in both groups and brain-derived neurotrophic factor (BDNF) in TG. The single exercise session was capable of inducing elevated HR, RPE, lactate level, and CK levels. This protocol changed the count/total number of circulating immune cells in both groups (UTG and TG) and also increased the level of plasmatic apelin, BDNF, and FLTS1 only in TG and FABP3 myokines in both groups.Item The prevalence of malnutrition and its risk factors in children attending outpatient clinics in the city of Manaus, Amazonas, Brazil.(2008) Maia, Marcelle Marie Martins; Fausto, Maria Arlene; Vieira, Érica Leandro Marciano; Benetton, Maria Linda Flora de Novaes; Carneiro, MariângelaO objetivo do estudo foi determinar a prevalência de desnutrição e fatores de risco em crianças de 0-10 anos, atendidas em ambulatórios em Manaus, Amazonas, Brasil. Foi conduzido um estudo epidemiológico transversal em uma amostra de 347 crianças. As entrevistas foram realizadas com os pais ou responsáveis, foram coletados dados socioeconômico e de consumo alimentar de cada criança. Para avaliação dietética utilizou-se um questionário semiquantitativo de freqüência alimentar. Amostras de fezes foram examinas por microscópio ótico. Medidas antropométricas foram transformadas em percentis e z-escore e o estado nutricional foi avaliado pelos indicadores do National Center for Health Statistics (NCHS) e do Centers for Disease Control (CDC). Fatores de risco associados à desnutrição foram analisados usando modelo de regressão logística com efeito aleatório. As prevalências de baixo peso, déficit de estatura e déficit de peso foram 18,1, 15,5 e 10,7% pela referência do CDC e 14,3, 17,3 e 4,4% do NCHS. A prevalência de déficit de peso foi maior quando estimada pelo CDC em comparação ao NCHS (p=0,02). A prevalência de parasitoses intestinais foi de 58,8%. Os fatores de risco associados a desnutrição foram: baixo nível educacional dos respondentes (OR=4.55), ingestão calórica <54.5 kcal/kg (OR=4.55), crianças na faixa etária de 6-10 anos (OR=3.54), e consulta pediátrica como motivo de visita ao ambulatório (OR=2.71). Na população estudada, desnutrição (baixo peso, déficit de estatura e déficit de peso) e infecção parasitária ainda representam um problema de saúde pública. Os fatores de risco confirmam a influência dos fatores sócio econômicos no estado nutricional das crianças.