Navegando por Autor "Batista, Aline Priscila"
Agora exibindo 1 - 13 de 13
Resultados por página
Opções de Ordenação
Item Ancestralidade genética e marcadores de risco para a doença cardiovascular em distritos do município de Ouro Preto, Minas Gerais.(2019) Batista, Aline Priscila; Coelho, George Luiz Lins Machado; Queiroz, Erica Maria de; Coelho, George Luiz Lins Machado; Mendes, Ana Paula Carlos Cândido; Chianca Júnior, Deoclécio Alves; Freitas, Renata Nascimento de; Franceschini, Sylvia do Carmo CastroEssa proposta pretende determinar a associação entre marcadores informativos de ancestralidade genética (MIAs), marcadores genéticos e os fatores de risco cardiovascular (FRCV) clássicos nos distritos de Lavras Novas, Chapada e Santo Antônio do Salto, em Ouro Preto/MG. Foi realizado um estudo transversal com 515 participantes onde foram avaliadas as variáveis clínicas, antropométricas e bioquímicas para definição dos FRCV: hipertensão arterial sistêmica (HAS), diabetes mellitus tipo 2, dislipidemia, obesidade e sobrepeso. A adipocina quemerina foi avaliada como FRCV emergente. As estimativas das proporções de ancestralidade individual e geral foram realizadas considerando 3 populações parentais: Europeia, Africana e Ameríndia. Também foi determinada a frequência alélica e genotípica utilizando um painel de 12 polimorfismos do tipo SNP e testadas quanto ao Equilíbrio de Hardy-Weinberg. A prevalência de hipertensos (43%), diabéticos (10%), dislipidêmicos (63,3%), obesos (22,1%) e de sobrepeso (33%) foi elevada, sendo observada uma maior proporção de todos os fatores de risco entre as mulheres. A média da concentração plasmática de quemerina foi 203,8 ± 119,4 ng/mL, com diferença significativa entre homens e mulheres. A análise de proporção dos MIAs mostrou 48% de ancestralidade europeia, 41% de ancestralidade africana e 11% de ancestralidade ameríndia. Segundo a predominância de um grupo parental ou presença de miscigenação observou-se uma população majoritariamente miscigenada com 313 (86,5%) indivíduos compondo esse grupo. As variáveis que chamaram a atenção foram o colesterol total, triacilgliceróis e as frações HDL-c e não-HDL-c sendo que para todas foram observados maiores valores médios no grupo com predominância africana. A presença concomitante dos genótipos de risco AA e GT+TT dos SNPs APOB rs693 e NOS3 rs1799983, respectivamente, mostrou maior chance de apresentar a concentração plasmática elevada de quemerina quando comparado ao genótipo de referência (GG). A presença do alelo T do SNP RARRES2 rs4721 apresentou gradiente de risco dependente com as variáveis comportamentais, bioquímicas, idade e diabetes na determinação da chance de ter HAS, a qual aumentou nos homozigotos de risco em relação aos heterozigotos. Portanto, conclui-se que a população apresenta o padrão de ancestralidade esperado para região Sudeste, formado pela miscigenação de europeus e africanos principalmente. Entretanto observou-se maior influência africana em relação a área urbana de Ouro Preto e outras regiões no Sudeste brasileiro. A autoclassificação de cor de pele foi inconsistente com a ancestralidade genética. A elevação da concentração plasmática de quemerina pode ser um importante preditor de risco cardiovascular e pode interagir com as variantes NOS3 rs1799983 e APOB rs693 promovendo a DCV, e um mecanismo provável pode ser a disfunção no endotélio vascular. Por último, a influência do SNPs RARRES2 rs4721 na adiposidade visceral pode ser um importante predisponente ao risco cardiovascular, e a interação de seu alelo T com outros fenótipos de risco pode ser um fator genético modificador do efeito de fatores de risco clássicos para a HAS.Item COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020 : study protocol and initial results.(2023) Meireles, Adriana Lúcia; Lourenção, Luciano Garcia; Menezes Junior, Luiz Antonio Alves de; Coletro, Hillary Nascimento; Justiniano, Irene Carolina Sousa; Moura, Samara Silva de; Diniz, Amanda Popolino; Sabião, Thaís da Silva; Rocha, Ana Maria Sampaio; Batista, Aline Priscila; Lage, Nara Nunes; Simões, Bárbara dos Santos; Santos, Carolina Ali; Mendonça, Raquel de Deus; Andrade, Amanda Cristina de Souza; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Carraro, Júlia Cristina Cardoso; Menezes, Mariana Carvalho de; Nascimento, Renata Cristina Rezende Macedo do; Roever, Leonardo; Caiaffa, Waleska Teixeira; Coelho, George Luiz Lins MachadoObjective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to- face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.Item CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women.(2017) Ribeiro, Silvana Mara Luz Turbino; Lopes, Laís Roquete; Costa, Guilherme de Paula; Figueiredo, Vivian Paulino; Bajracharya, Deena Shrestha; Batista, Aline Priscila; Nicolato, Roney Luiz de Carvalho; Oliveira, Fernando Luiz Pereira de; Estanislau, Juliana de Assis Silva Gomes; Silva, André Talvani Pedrosa daThe current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status. In total, 117 women were selected and grouped as eutrophic, overweight, and obese, according to anthropometric parameters. Analyses of anthropometric and circulating biochemical parameters were followed by plasma immunoassays for CXCL-16, IL- 17, and BMP-2.Item Factors associated with non-use of condoms and prevalence of HIV, viral hepatitis B and C and syphilis : a cross-sectional study in rural communities in Ouro Preto, Minas Gerais, Brazil, 2014-2016.(2019) Barbosa, Keila Furbino; Batista, Aline Priscila; Nacife, Maria Beatriz Pena e Silva Leite; Vianna, Valeska Natiely; Oliveira, Wandeir Wagner de; Machado, Elaine Leandro; Marinho, Carolina Coimbra; Coelho, George Luiz Lins MachadoObjective: to investigate socio-demographic factors associated with non-use of condoms, and to describe the prevalence of sexually transmitted infections (STI) in rural communities of Ouro Preto, Minas Gerais, Brazil, 2014 to 2016. Methods: data were gathered from individual interviews and rapid tests were performed; associations were tested using Poisson regression, with a 95% confidence interval (95%CI). Results: we detected 3.8 cases/10,000 inhabitants for hepatitis B and syphilis, and 1.3 cases/10,000 inhabitants for hepatitis C; no HIV cases were detected; in the multivariate analysis we found higher prevalence rates of condom non-use among the group of individuals who were married, had common law partners or were widowed (PR=1.20 – 95%CI 1.06;1.36). Conclusion: individuals in a stable relationship formed the group with the highest prevalence rate of condom non-use; new syphilis and viral hepatitis cases were detected using rapid tests during the survey.Item High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil.(2020) Batista, Aline Priscila; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Queiroz, Erica Maria de; Marinho, Carolina Coimbra; Cândido, Ana Paula Carlos; Coelho, George Luiz Lins MachadoChemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI: 1.23–2.98], insulin resistance (OR=1.82, 95%CI: 1.03–3.22), age (OR=1.64, 95%CI: 1.08–2.49), and sex (OR=1.99, 95%CI: 1.35–2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI: 1.03–2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI: 1.01–2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI: 1.25–3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.Item High levels of glycated hemoglobin (HbA1c) are associated with physical inactivity, and part of this association is mediated by Bbeing overweight.(2023) Moura, Samara Silva de; Menezes Júnior, Luiz Antônio Alves de; Rocha, Ana Maria Sampaio; Batista, Aline Priscila; Menezes, Mariana Carvalho de; Carraro, Júlia Cristina Cardoso; Coelho, George Luiz Lins Machado; Meireles, Adriana LúciaThe COVID-19 pandemic has generated substantial changes in the lives of the population, such as increased physical inactivity, which can lead to being overweight and, consequently, repercussions on glucose homeostasis. A cross-sectional study based on the adult population of Brazil was conducted by stratified, multistage probability cluster sampling (October and December 2020). Participants were classified as physically active or inactive during leisure time according to the recommendations of the World Health Organization. HbA1c levels were categorized as normal (≤6.4%) or with glycemic changes (≥6.5%). The mediating variable was being overweight (overweight and obese). Descriptive, univariate, and multivariate logistic regression analyses examined the association between physical inactivity and glycemic changes. Mediation was analyzed using the Karlson–Holm–Breen method to verify the influence of being overweight on the association. We interviewed 1685 individuals, mostly women (52.4%), 35–59 years old (45.8%), race/ethnicity brown (48.1%), and overweight (56.5%). The mean HbA1c was 5.68% (95% CI: 5.58–5.77). Mediation analysis verified that physically inactive participants during leisure time were 2.62 times more likely to have high levels of HbA1c (OR: 2.62, 95% CI: 1.29–5.33), and 26.87% of this effect was mediated by over-weight (OR: 1.30: 95% CI: 1.06–1.57). Physical inactivity at leisure increases the chances of high levels of HbA1c, and part of this association can be explained by being overweight.Item Hipovitaminose D associa-se a adiposidade visceral, níveis elevados de lipoproteína de baixa densidade e triglicérides em trabalhadores de turno alternante da microrregião dos Inconfidentes, Minas Gerais, Brasil.(2015) Batista, Aline Priscila; Coelho, George Luiz Lins Machado; Nascimento Neto, Raimundo Marques doIntrodução : O termo vitamina D compreende um grupo de moléculas secoesteroídes, atuando classicamente no metabolismo ósseo e na homeostase do cálcio. Seres humanos obtém a vitamina D pela fotoativação na pele através da exposição aos raios solares ultravioleta B e pela ingestão na dieta. O calcidiol [25(OH)D] é o marcador bioquímico que melhor reflete o status da vitamina D, e o metabólito ativo, o calcitriol [1,25-(OH)2D], é o que age como um hormônio esteroide. Estudos sugerem que exista uma forte associação de baixos níveis de vitamina D com a doença cardiovascular e com seus fatores de risco. A hipovitaminose D (25(OH)D < 30 ng/mL) é um recente problema de saúde pública, que vem atingindo diferentes populações. Objetivo: Investigar se a hipovitaminose D é um mecanismo adicional para explicar os distúrbios no perfil lipídico e excesso adiposidade abdominal apresentados por trabalhadores de turno alternante de uma mineradora da região dos Inconfidentes, Minas Gerais, Brasil. Metodologia : Estudo transversal foi conduzido em uma amostra de 391 indivíduos adultos do sexo masculino, de 20 a 57 anos, em regime de turnos alternantes que apresentavam, pelo menos, um critério de risco para doenças cardiovasculares. Foram obtidas variáveis demográficas, comportamentais, clínicas, antropométricas e de composição corporal. Uma amostra de sangue foi obtida para dosagem de 25(OH)D, paratormônio molécula intacta, cálcio, fósforo, perfil lipídico, glicemia, insulinemia, proteína C reativa e adipocinas. Resultados: A média de idade dos 391 participantes do estudo foi de 36,1 ± 7,3. O percentual de hipovitaminose D e de dislipidemia foi de 73% e 74,2%, respectivamente. A gordura visceral em excesso se mostrou significativa no grupo hipovitaminose D, com OR de 2,3 (IC 95%: 1,3-4,0). Dislipidêmicos apresentaram níveis de 25(OH)D significativamente menor (OR = 2.7, IC95% = 1.6-4,3) do que os indivíduos com níveis normais de colesterol total e frações e triglicérides. Após ajuste por idade e sazonalidade, os níveis de vitamina D tiveram uma associação inversa significativa e dose dependente com lipoproteína de baixa densidade (OR: 5,9), triglicérides (OR: 2,4) e gordura visceral (OR: 2,3). Conclusão: Nossos resultados sugerem que a adiposidade visceral em excesso é um forte preditor da hipovitaminose D e associada a hipertriglicemia aumenta o risco de hipovitaminose D. Adicionalmente nossos resultados sugerem que a hipovitaminose D possa por sua vez ser um forte contribuinte para o fenótipo lipídico aterogênico da Síndrome Metabólica.Item Hypertension is associated with a variant in the RARRES2 gene in populations of Ouro Preto, Minas Gerais, Brazil : a cross-sectional study.(2021) Batista, Aline Priscila; Barbosa, Keila Furbino; Azevedo, Rafael Júnior de; Vianna, Valeska Natiely; Queiroz, Erica Maria de; Marinho, Carolina Coimbra; Coelho, George Luiz Lins MachadoBackground: Arterial hypertension (AH) is implicated in vascular health and contributes significantly to cardiovascular morbidity and mortality. In addition to the contribution of usual risk factors for AH, elucidating the influence of genetic factors is a promising area of investigation. Therefore, we evaluated the association between AH and cardiovascular risk factors (CVRFs) and genetic polymorphisms in communities in Southeast Brazil. Methods: A total of 515 adults aged 18-91 years, who were cross-sectionally assessed between 2015-2016, were included. Demographic, clinical, behavioral, anthropometric characteristics, and laboratory parameters and 12 single nucleotide polymorphisms in seven candidate genes involved in cardiovascular risk (RARRES2, AGT, NOS3, GNB3, APOE, APOB, APOC3, LDLR, and PPARG) were evaluated, with AH as the outcome. Sex, age, and laboratory parameters were considered the main confounding factors. Results: There was a significant association between age >60 years (odds ratio [OR] =6.74), alcohol dependence (OR=3.84), smoking (OR=1.74), overweight (OR=1.74), high plasma triglyceride (TG) levels (OR=1.98) and low high-density lipoprotein (HDL-c) (OR=6.22), diabetes (OR=3.68), and insulin resistance (OR=2.40) and AH. A significant association was observed between rs4721 in RARRES2 and AH. The T allele in homozygosis was a potent chance modifier for AH. The highest chance gradients for AH were characterized by the presence of the TT genotype and DMT2 (OR=9.70), high TG (OR=6.26), low HDL-c (OR=8.20), and age more than 60 years (OR=9.96). Conclusion: The interaction of the T allele of the rs4721 polymorphism in RARRES2 with CVRFs may predispose carriers to a higher cardiovascular risk.Item Hypovitaminosis D is associated with visceral adiposity, high levels of low-density lipoprotein and triglycerides in alternating shift workers.(2016) Batista, Aline Priscila; Ambrosim, Ticiana Vazzoler; Nascimento Neto, Raimundo Marques do; Pimenta, Fausto Aloísio Pedrosa; Freitas, Silvia Nascimento de; Lauria, Márcio Weissheimer; Coelho, George Luiz Lins MachadoBackground: Studies suggest that there is a strong association between low vitamin D levels and cardiovascular disease (CVD) and its risk factors (RFs). Hypovitaminosis D (25(OH)D < 30 ng/mL or 75 nmol/L) is a recent public health problem that has reached different populations. The objective of the study was to investigate whether hypovitaminosis D is an additional mechanism to explain the disturbances in the lipid profile as well as the excess of abdominal fat presented by alternating shift workers of a mining company in the region of Inconfidentes, Minas Gerais, Brazil. Methods: A cross-sectional study was conducted in a sample of 391 adult males, aged 20 - 57 years old and working alternating shifts, who had at least one risk criterion for CVD. Demographic, behavioral, clinical, and anthropometric and body composition variables were obtained. A blood sample was drawn for determining 25(OH) D, parathyroid hormone intact molecule, lipid profile, blood glucose, insulin, C-reactive protein, and adipokines. Results: The average age of the 391 study participants was 36.1 ± 7.3 years. The percentage of hypovitaminosis D and dyslipidemia was 73% and 74.2%, respectively. Excess visceral fat was significant in the hypovitaminosis D group, with an odds ratio (OR) of 2.4 (95% confidence interval (CI): 1.1 - 5.2). Dyslipidemia showed 25(OH)D levels significantly lower (OR: 2.7, 95% CI: 1.6 - 4.3) than in individuals with normal levels of cholesterol and fractions, and triglycerides. After adjusted the analysis by age and seasonality, the vitamin levels had a significant inverse association and dose-dependent with lowdensity lipoprotein (OR: 5.9), triglycerides (OR: 2.3) and visceral fat area (OR: 2.4). Conclusion: Hypovitaminosis D and dyslipidemia were found in the majority of our mining company shift workers. Furthermore, excess visceral adiposity, hypertriglyceridemia and high low-density lipoprotein cholesterol levels are strong predictors of hypovitaminosis D.Item Influence of sunlight on the association between 25-hydroxyvitamin D levels and sleep quality in Brazilian adults : a population-based study.(2023) Menezes Júnior, Luiz Antônio Alves de; Sabião, Thaís da Silva; Moura, Samara Silva de; Batista, Aline Priscila; Menezes, Mariana Carvalho de; Carraro, Júlia Cristina Cardoso; Andrade, Amanda Cristina de Souza; Coelho, George Luiz Lins Machado; Meireles, Adriana LúciaObjectives: This study aimed to evaluate the association of vitamin D with sleep quality during the COVID-19 pandemic and the influence of daily sunlight on this association. Methods: This cross-sectional, population-based study among adults stratified by multistage probability cluster sampling was conducted from October to December 2020 in the Iron Quadrangle region of Brazil. The outcome was sleep quality, evaluated by the Pittsburgh Sleep Quality Index. Vitamin D (25-hydroxyvitamin D) concentrations were determined by indirect electrochemiluminescence and a deficiency was classified as 25 (OH)D < 20 ng/mL. To assess sunlight, the average daily sunlight exposure was calculated and was classified as insufficient when less than 30 min/d. Multivariate logistic analysis was used to estimate the association between vitamin D and sleep quality. A directed acyclic graph was used to select minimal and sufficient sets of adjustment variables for confounding from the backdoor criterion. Results: In a total of 1709 individuals evaluated, the prevalence of vitamin D deficiency was 19.8% (95% CI, 15.5 24.9%), and the prevalence of poor sleep quality was 52.5% (95% CI, 48.6 56.4%). In multivariate analysis, vitamin D was not associated with poor sleep quality in individuals with sufficient sunlight. Moreover, in individuals with insufficient sunlight, vitamin D deficiency was associated with poor sleep quality (odds ratio [OR], 2.02; 95% CI, 1.10 3.71). Furthermore, each 1-ng/mL increase in vitamin D levels reduced the chance of poor sleep quality by 4.2% (OR, 0.96; 95% CI, 0.92 0.99). Conclusions: Vitamin D deficiency was associated with poor sleep quality in individuals with insufficient exposure to sunlight.Item Lung function of patients hospitalized with COVID-19 at 45 days after hospital discharge : first report of a prospective multicenter study in Brazil.(2021) Mancuzo, Eliane Viana; Marinho, Carolina Coimbra; Coelho, George Luiz Lins Machado; Batista, Aline Priscila; Andrade, Bruno Horta; Brandão, Álvaro Lucca Torres; Leite, Ana Sophia Mitre; Ferreira, Pedro Chaves; Roveda, José Reinaldo Corrêa; Leite, Arnaldo Santos; Augusto, Valéria MariaObjective: Because SARS-CoV-2 infection can severely affect the lungs and persistent functional changes can occur after severe disease, we aimed to determine lung function parameters of COVID-19 patients at 45 days after hospital discharge and compare changes according to the severity of the disease. Methods: This was a prospective descriptive analytical multicenter study. The participants were allocated into three groups: ward admission (WA) group; ICU admission not on mechanical ventilation (ICU/ MV−) group; and ICU admission on MV (ICU/MV+) group. Lung volumes, DLco, MIP, MEP, and six-minute walk distance (6MWD) were measured 45 days after discharge. Results: The sample comprised 242 patients (mean age = 59.4 ± 14.8 years; 52.1% of males), and 232 (96%) had altered lung function. In the total cohort, restrictive disorder was observed in 96%, as well as reductions in DLco (in 21.2% of the patients), FEV1 /FVC (in 39.7%), and PEmax (in 95.8%), with no differences between the groups. Comparing the groups, the ICU/MV+ group had reduced DLco in 50% of the patients (p < 0.001) and a lower mean 6MWD % of the predicted value (p = 0.013). Oxygen desaturation in the six-minute walk test was observed in 32.3% of the cohort and was less frequent in the IE group. Conclusions: This is the first South American study involving severe COVID-19 survivors whose lung function was assessed 45 days after hospital discharge. Changes were frequent, especially in those on MV, which highlights the importance of lung function evaluation after severe COVID-19.Item Lung function six months after severe COVID-19 : does time, in fact, heal all wounds?(2022) Bretas, Daniel Cruz; Leite, Arnaldo Santos; Mancuzo, Eliane Viana; Prata, Tarciane Aline; Andrade, Bruno Horta; Oliveira, Jacqueline das Graças Ferreira; Batista, Aline Priscila; Coelho, George Luiz Lins Machado; Augusto, Valéria Maria; Marinho, Carolina CoimbraBackground COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease. Methods We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon monoxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis. Results 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed significant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC, FEV1, total lung capacity, and 6MW distance measures. The improvement in the proportions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m; p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001). Conclusion Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital discharge. The difference was more evident in those requiring ICU admission.Item Percentage of energy contribution according to the degree of industrial food processing and associated factors in adolescents (EVA-JF study, Brazil).(2021) Melo, Adriana Soares Torres; Neves, Felipe Silva; Batista, Aline Priscila; Coelho, George Luiz Lins Machado; Sartorelli, Daniela Sales; Faria, Eliane Rodrigues de; Netto, Michele Pereira; Oliveira, Renata Maria Souza; Fontes, Vanessa Sequeira; Cândido, Ana Paula CarlosObjective: To evaluate energetic contribution according to the degree of industrial food processing and its association with sociodemographic, anthropometric, biochemical, clinical and behavioural characteristics in adolescents. Design: Cross-sectional study (Adolescent Lifestyle Study). Food consumption was assessed using 24-h dietary recalls, with foods classified by degree of industrial progressing. The usual diet was estimated using the Multiple Source Method. In a linear regression model, the energy percentage (E %) was associated with sociodemographic, anthropometric, biochemical, clinical and behavioural characteristics, after adjustment for sex and age. Setting: Juiz de Fora, Brazil. Participants: Eight hundred and four adolescents, of both sexes, 14–19 years of age, enrolled in public schools. Results: The E % of unprocessed or minimally processed foods corresponded to 43·1 %, processed foods to 11·0 % and the ultraprocessed foods to 45·9 %. E % of unprocessed foods was associated with socio-economic stratum (adjusted β = −0·093; P = 0·032), neck circumference (adjusted β = 0·017; P = 0·049), screen time (adjusted β = −0·247; P = 0·036) and HDL-cholesterol (adjusted β = −0·156; P = 0·003). E % of ultraprocessed foods was associated with socio-economic stratum (adjusted β = 0·118; P = 0·011), screen time (adjusted β = 0·375; P = 0·003), BMI (adjusted β = −0·029; P = 0·025), neck circumference (adjusted β = −0·017; P = 0·028) and HDL-cholesterol (adjusted β = 0·150; P = 0·002). Conclusions: There was a high E % of ultraprocessed foods in the diet of the adolescents. Actions are needed to raise the awareness of adopting healthy eating habits.