Alvarenga, Dalila JunqueiraMatias, Laira Maria FariaCordeiro, Cleydson FinottiSouza, Thiago Belarmino deLavorato, Stefânia NeivaPereira, Marília Gabriella Alves GoulartDias, Danielle FerreiraCarvalho, Diogo Teixeira2021-12-072021-12-072020ALVARENGA, D. J. et al. Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme. Natural Product Research, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1827399?journalCode=gnpl20>. Acesso em: 10 jun. 2021.1478-6427http://www.repositorio.ufop.br/jspui/handle/123456789/14115We report here a series of glucosides which are active as inhibi tors of the angiotensin converting enzyme (ACE). They are struc turally related to the natural compound eugenol and exhibited significant inhibition values. Their syntheses were expeditious and we could obtain informative docking plots of them complexed to this enzyme. A glucoside derived from eugenol, carrying a carbox ylic group in the aglycone, was the most active of them (with an IC50 of 0.4 mM) and showed good binding energies in docking studies with ACE. Moreover, computational prediction of toxicity risks, physicochemical properties and drug score show that the glucoside derivative of eugenol is a suitable compound for opti misation studies aimed at finding new drug candidates.en-USrestritoArtigo publicado em periodicohttps://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1827399?journalCode=gnpl20https://doi.org/10.1080/14786419.2020.1827399