Barbosa, Marília Imaculada FrazãoCorrea, Rodrigo de SouzaPozzi, Lucas Vinícius dos SantosPavan, Fernando RogérioLeite, Clarice Queico FujimuraEllena, Javier AlcidesMachado, Sérgio de PaulaPoelhsitz, Gustavo VonBatista, Alzir Azevedo2016-10-052016-10-052015BARBOSA. M. I. F. et al. Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis. Polyhedron, v. 85, p. 376-382, 2015. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538714005889>. Acesso em: 26 set. 2016.02775387http://www.repositorio.ufop.br/handle/123456789/7034Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.en-USabertoMycobacterium tuberculosisRuthenium(II) complexesCytotoxicityMetallodrugsHydroxypyridinecarboxylatesArtigo publicado em periodicoO periódico Polyhedron concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3957611410935.https://doi.org/10.1016/j.poly.2014.08.057