Duarte, Lucienir PainsVieira Filho, Sidney AugustoSilva, Grácia Divina de FátimaSousa, José Rego dePinto, Artur da Silveira2014-11-142014-11-142002DUARTE, L. P. et al. Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 44, n.2, p. 109-112, 2002. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&nrm=iso&lng=pt&tlng=pt&pid=S0036-46652002000200010>. Acesso em: 20 ago. 2014.0036-4665http://www.repositorio.ufop.br/handle/123456789/3864Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20_-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.en-USAustroplenckia populneaPentacyclic triterpenesAnti-trypanosomal activityGrowth inhibitionArtigo publicado em periodicoA Revista do Instituto de Medicina Tropical de São Paulo permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida por email enviado no dia 06/12/2013.http://dx.doi.org/10.1590/S0036-46652002000200010