Santos, Stefânia Sales de OliveiraSinisterra Millán, Ruben DarioSpeziali, Marcelo Gomes2020-06-162020-06-162020SANTOS, S. S. O.; MILLÁN, R. D. S.; SPEZIALI, M. G. Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material. European Polymer Journal, v. 124, n. 109490, fev. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014305719320543>. Acesso em: 10 fev. 2020.0014-3057http://www.repositorio.ufop.br/handle/123456789/12353This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.en-USrestritoWeibull kinetic modelKorsmeyer – peppas kinetic modelpH-dependentSilanizationDesorptionArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0014305719320543https://doi.org/10.1016/j.eurpolymj.2020.109490