Doriguetto, Antônio CarlosMartins, Felipe TerraEllena, Javier AlcidesSalloum, RogérioSantos, Marcelo Henrique dosMoreira, Maria Eliza de CastroSilva, Jose Mauricio Schneedorf Ferreira daNagem, Tanus Jorge2017-06-192017-06-192007DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017.1612-1880http://www.repositorio.ufop.br/handle/123456789/7982The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.en-USrestritoArtigo publicado em periodicohttp://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstracthttps://doi.org/10.1002/cbdv.200790041