Wardini, Amanda BritoSilva, Lucia Helena Pinto daNadaes, Natalia RochaNascimento, Michelle Tanny Cunha doRoatt, Bruno MendesReis, Alexandre BarbosaViana, Kelvinson FernandesGiunchetti, Rodolfo CordeiroSaraiva, Elvira Maria2020-05-082020-05-082019WARDINI, A. B. et al. Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs. Scientific Reports, v. 9, n. 6247, p. 1-9, abr. 2019. Disponível em: <https://www.nature.com/articles/s41598-019-42687-9>. Acesso em: 10 fev. 2020.2045-2322http://www.repositorio.ufop.br/handle/123456789/12167Visceral leishmaniasis is a chronic disease that afects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Here, we evaluate the efector properties of neutrophils from healthy and naturally Leishmania infantum-infected dogs. Our results showed that the parasite induced neutrophil extracellular trap (NET) release from neutrophils in both groups. Additionally, phagocytosis and NETs contributed diferently to parasite killing by neutrophils from healthy and infected animals, and IFN-γ, IL-8, IL-4 and TNF-α production by neutrophils from both groups were diferentially modulated by the parasite. Our results contribute to a better understanding of the complex role played by neutrophils in canine visceral leishmaniasis, which may favor the development of more efective therapies.en-USabertoArtigo publicado em periodicoThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o próprio artigo.https://doi.org/10.1038/s41598-019-42687-9