Applying positive end-expiratory pressure during mechanical ventilation causes pulmonary redox imbalance and inflammation in rats.

Andrade, Mônica CamposSouza, Ana Beatriz Farias deHorta, Jacques GabrielCosta, Guilherme de PaulaSilva, André Talvani Pedrosa daCangussú, Silvia DantasMenezes, Rodrigo Cunha Alvim deBezerra, Frank Silva2018-05-112018-05-112018ANDRADE, M. C. et al. Applying positive end-expiratory pressure during mechanical ventilation causes pulmonary redox imbalance and inflammation in rats. SHOCK, v. 2018, p. 1-24, 2018. Disponível em: <https://insights.ovid.com/pubmed?pmid=29194341>. Acesso em: 05 abr. 2018.http://www.repositorio.ufop.br/handle/123456789/9916Mechanical ventilation may induce or aggravate lung injury through the production of cytokines, inflammatory infiltration of neutrophils and changes in the permeability of the alveolarcapillary barrier. The use of positive end-expiratory pressure (PEEP) helps improve gas exchanges avoiding alveolar collapse at the end of expiration. The present study aimed to analyze inflammatory response and redox imbalance in lungs of rats submitted to mechanical ventilation with and without positive end-expiratory pressure.en-USrestritoApplying positive end-expiratory pressure during mechanical ventilation causes pulmonary redox imbalance and inflammation in rats.Artigo publicado em periodicohttps://insights.ovid.com/pubmed?pmid=29194341