Pereira, C. C. S. S.Ferazzo, Fábio FerreiraSouza, Gilberto Henrique Bianco deFonseca, Fernando L. A.Rosa, Paulo César Pires2017-09-182017-09-182016PEREIRA, C. C. S. S. et al. Cubebin and semisynthetic dibenzyl butyrolactone derivatives: biological activities. African Journal of Pharmacy and Pharmacology, v. 10, p. 526, 2016. Disponível em: <http://www.academicjournals.org/journal/AJPP/article-abstract/63E989959487>. Acesso em: 29 ago. 2017.1996-0816http://www.repositorio.ufop.br/handle/123456789/8749Lignans are a group of secondary metabolites with a wide variety of chemical structures, formed by coupling two phenylpropanoid units. Currently, there is great interest in lignan due to the wide range of biological activities this class of compounds has demonstrated. This review describes the biological activities of cubebin and semi-synthetic derivatives, focusing primarily on Piper cubeba and Zantoxyllum naranjillo. The main biological activities reported were: Anti-inflammatory, antitumor, action in erectile dysfunction, trypanocidal, anti-Leishmania and antimicrobial. In this way, it is possible to conclude that cubebin and its derivatives have shown high capacity to become new bioactive molecules obtained by semi-sinthesys, useful to develop medicines for several pathologies, presenting efficacy, toxicology and quality for human use.en-USabertoLignansSemisynthetic derivativesPiper cubebaPiperaceaeZantoxyllum naranjilloArtigo publicado em periodicoAuthor(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License. Fonte: o próprio artigohttps://doi.org/10.5897/AJPP2015.4490