Silva, Pamela Félix daMatos, Natália Alves deRamos, Camila de OliveiraCastro, Thalles de FreitasAraújo, Natália Pereira da SilvaSouza, Ana Beatriz Farias deCosta, Guilherme de PaulaCangussú, Silvia DantasSilva, André Talvani Pedrosa daNagato, Akinori CardozoBezerra, Frank Silva2023-10-272023-10-272022SILVA, P. F. da et al. Acute outcomes of cigarette smoke and electronic cigarette aerosol inhalation in a murine model. BioMed Research International, artigo 9938179, 2022. Disponível em: <https://www.hindawi.com/journals/bmri/2022/9938179/>. Acesso em: 01 ago. 2023.2314-6141http://www.repositorio.ufop.br/jspui/handle/123456789/17680Cigarette smoking throughout life causes serious health issues in the lungs. The electronic cigarette (E-Cig) use increased, since it was first introduced in the world. This research work compared the short-term exposure consequences to e-cigarette vapor and cigarette smoke in male mice. Forty-five C57BL/6 mice were randomized into control (C) in an ambient air exposition cigarette smoke (CS) and aerosol electronic cigarette (EC), both were exposed to 120 puffs, 3 times/day during five days. Then, in the experimental protocol, the euthanized mice had their tissues removed for analysis. Our study showed that CS and EC resulted in higher cell influx into the airways, and an increase in macrophage counts in CS (209.25 ± 7.41) and EC (220.32 ± 8.15) when compared to C (108.40 ± 4.49) (p < 0:0001). The CS (1.92 ± 0.23) displayed a higher pulmonary lipid peroxidation as opposed to C (0.93 ± 0.06) and EC (1.23 ± 0.17) (p < 0:05). The EC (282.30 ± 25.68) and CS (368.50 ± 38.05) promoted increased levels of interleukin 17 when compared to C (177.20 ± 10.49) (p < 0:05). The EC developed shifts in lung histoarchitecture, characterized by a higher volume density in the alveolar air space (60.21; 55.00-65.83) related to C (51.25; 18.75-68.75) and CS (50.26; 43.75-62.08) (p =0.002). The EC (185.6 ± 9.01) presented a higher respiratory rate related to CS (133.6 ± 10.2) (p < 0:002). Therefore, our findings demonstrated that the short-term exposure to e-cig promoted more acute inflammation comparing to cigarette smoke in the ventilatory parameters of the animals.en-USabertoArtigo publicado em periodicoThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: PDF do artigo.https://doi.org/10.1155/2022/9938179