Mendonça, Michelle MendanhaCruz, Kellen Rosa daSilva, Fernanda Cacilda dos SantosFontes, Marco Antônio PelikyXavier, Carlos Henrique2023-12-062023-12-062022MENDONÇA, M. M. et al. Are hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection? Revista Brasileira de Psiquiatria, v. 44, n. 4, p. 434-440, 2022. Disponível em: <https://www.scielo.br/j/rbp/a/x6Gqm7JhhPVwkQkXys6BVvh/>. Acesso em: 01 ago. 2023.1809-452Xhttp://www.repositorio.ufop.br/jspui/handle/123456789/17903Follow-up of patients affected by COVID-19 has unveiled remarkable findings. Among the several sequelae caused by SARS-CoV-2 viral infection, it is particularly noteworthy that patients are prone to developing depression, anxiety, cognitive disorders, and dementia as part of the post-COVID-19 syndrome. The multisystem aspects of this disease suggest that multiple mechanisms may converge towards post-infection clinical manifestations. The literature provides mechanistic hypotheses related to changes in classical neurotransmission evoked by SARS-CoV-2 infection; nonetheless, the interaction of peripherally originated classical and non-canonic peptidergic systems may play a putative role in this neuropathology. A wealth of robust findings shows that hemoglobin-derived peptides are able to control cognition, memory, anxiety, and depression through different mechanisms. Early erythrocytic death is found during COVID-19, which would cause excess production of hemoglobin-derived peptides. Following from this premise, the present review sheds light on a possible involvement of hemoglobin-derived molecules in the COVID-19 pathophysiology by fostering neuroscientific evidence that supports the contribution of this non-canonic peptidergic pathway. This rationale may broaden knowledge beyond the currently available data, motivating further studies in the field and paving ways for novel laboratory tests and clinical approaches.en-USabertoCOVID-19SARS-CoV-2HemoglobinNeurotransmittersHemorphinsArtigo publicado em periodicoThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.https://doi.org/10.47626/1516-4446-2021-2339