Silva, Alessandra OliveiraProhaska, Clare C.Ceron, Carla Speroni2023-03-232023-03-232021SILVA, A. O.; PROHASKA, C. C.; CERON, C. S. Ethanol consumption and sepsis: mechanisms of organ damage. Journal of cellular signaling, v. 2, n. 4, p. 235-241, 2021. Disponível em: <https://www.scientificarchives.com/article/ethanol-consumption-and-sepsis-mechanisms-of-organ-damage#:~:text=Ethanol%20consumption%20in%20large%20quantities,in%20the%20development%20of%20sepsis.>. Acesso em: 11 out. 2022.2692-0638http://www.repositorio.ufop.br/jspui/handle/123456789/16422Sepsis is highly prevalent, and is one of the main causes of mortality among hospitalized patients. Ethanol consumption in large quantities compromises the normal functioning of the body, leading to dysfunction of multiple different organ systems. The association between sepsis and ethanol is not fully understood, but it is well accepted that ethanol consumption plays a role in the development of sepsis. Both sepsis and ethanol cause inflammatory dysfunction and promote oxidative stress. Antioxidant agents may be highly relevant targets to abrogate the effects of sepsis in patients who also consume large amounts of ethanol. This review focuses on presenting the main mechanisms involved between sepsis and ethanol consumption, and to describe the main antioxidants that have been used as therapeutic agents.en-USabertoEthanol consumptionSepsis mortalitySepsisOxidative stressAntioxidant defenseArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: o PDF do artigo.https://doi.org/10.33696/Signaling.2.056