Correa, Rodrigo de SouzaOliveira, Katia Mara dePérez, HiramPlutín Stevens, Ana MaríaRamos Cairo, RaúlMocelo, RaúlCastellano, Eduardo ErnestoBatista, Alzir Azevedo2020-06-182020-06-182019CORREA, R. S. et al. cis-bis(N-benzoyl-N0 ,N0 -dibenzylthioureido) platinum(II): synthesis, molecular structure and its interaction with human and bovine serum albumin. Arabian Journal of Chemistry, v. 12, n. 8, p. 3454-3462, dez. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1878535215003020>. Acesso em: 10 fev. 2020.1878-5352http://www.repositorio.ufop.br/handle/123456789/12370In this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C–H⋯C, C–H⋯S and H⋯H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M−1 and 104 M−1, respectively. Thermodynamic parameters (ΔG, ΔH and ΔS) suggest spontaneous interactions between complex and the proteins.en-USabertoPlatinum complexBenzoylthioureaHirshfeld surfaceArtigo publicado em periodicoThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Fonte: o próprio artigo.https://doi.org/10.1016/j.arabjc.2015.10.006