Silva, Juliana Figueira daBinda, Nancy ScarduaPereira, Elizete Maria RitaLavor, Mário Sérgio Lima deVieira, Luciene BrunoSouza, Alessandra Hubner deRigo, Flávia KarineFerrer, Hèlia TenzaCastro Junior, Célio José deFerreira, JulianoGomez, Marcus Vinicius2022-11-042022-11-042021SILVA, J. F. da. et al. Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 27, 2021. Disponível em: <https://www.scielo.br/j/jvatitd/a/fsmrGLSSTVR7qvvwCRg9VFj/>. Acesso em: 11 out. 2022.1678-9199http://www.repositorio.ufop.br/jspui/handle/123456789/15754Phα1β is a neurotoxin purified from spider venom that acts as a high-voltage-activated (HVA) calcium channel blocker. This spider peptide has shown a high selectivity for N-type HVA calcium channels (NVACC) and an analgesic effect in several animal models of pain. Its activity was associated with a reduction in calcium transients, glutamate release, and reactive oxygen species production from the spinal cord tissue and dorsal ganglia root (DRG) in rats and mice. It has been reported that intrathecal (i.t.) administration of Phα1β to treat chronic pain reverted opioid tolerance with a safer profile than ω-conotoxin MVIIA, a highly selective NVACC blocker. Following a recent development of recombinant Phα1β (CTK 01512-2), a new molecular target, TRPA1, the structural arrangement of disulphide bridges, and an effect on glial plasticity have been identified. CTK 01512-2 reproduced the antinociceptive effects of the native toxin not only after the intrathecal but also after the intravenous administration. Herein, we review the Phα1β antinociceptive activity in the most relevant pain models and its mechanisms of action, highlighting the impact of CTK 01512-2 synthesis and its potential for multimodal analgesia.en-USabertoPainAnalgesiaPhα1β peptideVoltage-activated calcium channelsArtigo publicado em periodicoThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Fonte: o PDF do artigo.https://doi.org/10.1590/1678-9199-JVATITD-2021-0001