Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.

Teixeira Neto, Rafael GonçalvesGiunchetti, Rodolfo CordeiroCarneiro, Cláudia MartinsVitor, Ricardo Wagner de AlmeidaVital, Wendel CouraQuaresma, Patrícia FláviaKer, Henrique GamaMelo, Lutiana Amaral deGontijo, Célia Maria FerreiraReis, Alexandre Barbosa2012-07-042012-07-042010TEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012.03044017http://www.repositorio.ufop.br/handle/123456789/959The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG totalen-USCanine visceral leishmaniasisParasite burdenImmunoglobulin avidityRelationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.Artigo publicado em periodicoO periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280860053397.