Graminha, Angelica EllenPopolin, CecíliaAraujo Neto, João Honorato deCorrea, Rodrigo de SouzaOliveira, Katia Mara deGodoy, Luani RezendeColina Vegas, Legna AndreinaEllena, Javier AlcidesBatista, Alzir AzevedoCominetti, Márcia Regina2023-11-242023-11-242022GRAMINHA, A. E. et al. New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway. European Journal of Medicinal Chemistry, v. 243, artigo 114772, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0223523422006742>. Acesso em: 01 ago. 2023.0223-5234http://www.repositorio.ufop.br/jspui/handle/123456789/17870In this work we present the synthesis and characterization of six new ruthenium compounds with general formulae [Ru(L)(dppb)(bipy)]PF6 and [Ru(L)(dppe)2]PF6 where L = salicylic acid (Sal), 4-aminosalicylic acid (AmSal) or 2,4-dihydroxybenzoic acid (DiSal), dppb = 1,4-bis(diphenylphosphino)butane, dppe = 1,2-bis (diphenylphosphino)ethane and bipy = 2,2′ -bipyridine. The complexes were characterized by elemental analysis, molar conductivity, cyclic voltammetry, NMR, UV–vis and IR spectroscopies, and two by X-ray crystallography. The 31P{1 H} NMR spectra of the complexes with the general formula [Ru(L)(dppe)2]PF6 showed that the phosphorus signals are solvent-dependent. Aprotic solvents, which form strong hydrogen bonds with the complexes, inhibit the free rotation of the salicylic acid-based, modifying the diphosphine cone angles, leading to distortion of the phosphorus signals in the NMR spectra. The cytotoxicity of the complexes was evaluated in MCF7, MDA-MB-231, SKBR3 human breast tumor cells, and MCF-10 non-tumor cell lines. The complexes with the structural formula [Ru(L)(dppe)2]PF6 were the most cytotoxic, and the complex [Ru(AmSal)(dppe)2]PF6 with L = 4-aminosalicylic acid ligand was the most selective for the MDA-MB-231 cell line. This complex interacts with the transferrin and induces apoptosis through the intrinsic pathway, as demonstrated by increased levels of proteins involved in apoptotic cell death.en-USrestritoRuthenium complexesSalicylic acidsCytotoxicityCell deathArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0223523422006742https://doi.org/10.1016/j.ejmech.2022.114772