Belo, Valéria AparecidaPereira, Jéssica AssisSouza, Sara Franchin Duarte deTana, Fernanda de LimaPereira, Bruna PinheiroLopes, Débora de OliveiraCeron, Carla SperoniNovaes, Rômulo DiasCorsetti, Patrícia PaivaAlmeida, Leonardo Augusto de2023-03-232023-03-232020BELO, V. A. et al. The role of IL‐10 in immune responses against Pseudomonas aeruginosa during acute lung infection. Cell and tissue research, v. 383, p. 1123–1133, 2020. Disponível em: <https://link.springer.com/article/10.1007/s00441-020-03308-4#:~:text=Despite%20the%20onset%20of%20the,Apidianakis%202013%3B%20Hazlett%20et%20al.>. Acesso em: 11 out. 2022.1432-0878http://www.repositorio.ufop.br/jspui/handle/123456789/16419Pseudomonas aeruginosa is considered an opportunistic pathogen of great clinical importance. The clearance of this bac- terium occurs through recognition of the pathogen by innate immune system receptors, leading to a lung infammatory response. However, this response must be controlled via immunoregulatory pathways. In this study, we evaluate the role of endogenous murine IL-10 after acute infection with the virulent strain P. aeruginosa PA14. To assess the role of IL-10, intratracheal infection with the PA14 strain was performed in C57BL/6 or IL-10 KO mice. The PA14 strain was recovered in both types of animals, although IL-10 KO mice presented a higher number of viable bacteria in the lung when compared to the C57BL/6 group. Histopathological and stereological analyses showed that IL-10 KO mice had higher tissue damage and infammatory infltrate when compared to control animals. The activity of MMP-9 but not MMP-2, as well as IL-6 and TNF-α expression, were augmented in the lungs of infected animals and was much more evident in IL-10 KO animals when compared to the other analyzed groups. This work indicates that endogenous IL-10 control P. aeruginosa infection, the expression of pro-infammatory genes, MMP-9 activity and histopathological processes of the infectious process in question.en-USrestritoImmunoregulationInterleukin-10Lung infectionInfammatory responseArtigo publicado em periodicohttps://link.springer.com/article/10.1007/s00441-020-03308-4#:~:text=Despite%20the%20onset%20of%20the,Apidianakis%202013%3B%20Hazlett%20et%20alhttps://doi.org/10.1007/s00441-020-03308-4