Silva, Marco Aurélio dos SantosNagato, Akinori CardozoTrajano, Eduardo Tavares LimaAlves, Jackson NogueiraBandeira, Ana Carla BaltharPorto, Luís Cristovão de Moraes SobrinoBezerra, Frank Silva2016-01-282016-01-282013SILVA, M. A. dos S. et al. The oxidative response of mouse hearts is modulated by genetic background. Arquivos Brasileiros de Cardiologia, v. 100, p. 157-163, 2013. Disponível em: <http://www.scielo.br/pdf/abc/v100n2/en_v100n2a08.pdf>. Acesso em: 21 out. 2015.1678-4170http://www.repositorio.ufop.br/handle/123456789/6253Background: Smoking plays an important role in cardiovascular diseases. However, the reasons why some individuals develop those diseases and others do not remain to be explained. Objective: This study aimed at assessing the redox profile of the heart of different mouse strains after exposure to cigarette smoke. Methods: Male mice of the Swiss (n = 10), C3H (n = 10), BALB/c (n = 10) and C57BL/6 (n = 10) strains were exposed to cigarette smoke (12 cigarettes/day), while their respective controls (n = 10) were exposed to ambient air for 60 days. After being euthanized, their heart was removed for biochemical analyses. Results: Although the malondialdehyde content did not increase in any of the groups, catalase activity decreased in the Swiss (p < 0.05) and BALB/c (p < 0.05) strain mice as compared with their respective control groups, while myeloperoxidase decreased in the C3H (p < 0.05) and C57BL/6 (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione content decreased in the Swiss, C3H, C57BL/6 (p < 0.05) and BALB/c (p < 0,001) strain mice as compared with their respective control groups. Regarding reduced glutathione content, an increase was observed in the Swiss strain mice (p < 0.05), while a decrease was observed in the C3H (p < 0.05) and BALB/c (p < 0.001) strain mice as compared with their respective control groups. The reduced glutathione/reduced glutathione ratio showed a reduction in the Swiss and C57BL/6 (p < 0.05) strain mice as compared with their respective control groups. Conclusion: The genetic background of mice can influence the antioxidant response after exposure to cigarette smoke and seems to be a determinant factor for redox imbalance in Swiss and C57BL/6 strain mice. Understanding antioxidant responses and genetic background of C3H and BALB/c strain mice might provide important information regarding cardiac resistance to cigarette smoke.en-USOxidative stressTobaccoSmokeGenetic enhancementMiceArtigo publicado em periodicoTodo o conteúdo do periódico Arquivos Brasileiros de Cardiologia, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Arquivos Brasileiros de Cardiologia <http://www.scielo.br/scielo.php?script=sci_serial&pid=0066-782X&lng=en&nrm=iso>. Acesso em: 19 ago. 2019.http://dx.doi.org/10.5935/abc.20130029