Torres, Rosália MoraisCorreia, DalmoNunes, Maria do Carmo PereiraDutra, Walderez OrnelasSilva, André Talvani Pedrosa daSousa, Andréa SilvestreMendes, Fernanda de Souza Nogueira SardinhaScanavacca, Maurício IbrahimPisani, CristianoMoreira, Maria da Consolação VieiraSouza, Dilma do Socorro Moraes deOliveira Junior, Wilson deMartins, Silvia MarinhoDias, João Carlos Pinto2023-10-272023-10-272022TORRES, R. M. et al. Prognosis of chronic Chagas heart disease and other pending clinical challenges. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, artigo e210172, 2022. Disponível em: <https://www.scielo.br/j/mioc/a/9Q88qzbCyckqdB8TFHKTsQb/>. Acesso em: 01 ago. 2023.1678-8060http://www.repositorio.ufop.br/jspui/handle/123456789/17683In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.en-USabertoChagas cardiomyopathyEvolution markersPublic healthArtigo publicado em periodicoThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Fonte: PDF do artigo.https://doi.org/10.1590/0074-02760210172