Pereira, Daniela A.Sandrim, Valeria CristinaPalei, Ana Carolina TaveirosSantos, José Eduardo Tanus dosBelo, Vanessa de AlmeidaCavalli, Ricardo de CarvalhoLuizon, Marcelo Rizzatti2022-12-072022-12-072019PEREIRA, D. A. et al. NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia. Pregnancy Hypertension, v. 18, p. 137-140, 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S2210778919304489?via%3Dihub>. Acesso em: 11 out. 2022.2210-7789http://www.repositorio.ufop.br/jspui/handle/123456789/15879NAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = −0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = −0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in pre- eclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.en-USrestritoNicotinamide phosphorybosil transferaseNitrite levelsPreeclampsiaVisfatin / NAMPTArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S2210778919304489?via%3Dihubhttps://doi.org/10.1016/j.preghy.2019.09.022