Silva Júnior, Otávio de MeloNunes, Cristiana BuzelinCorrêa, Tchalton AmadorSilva, Marilia F.Freitas, Laurice BarbosaAlberti, Luiz Ronaldo2019-04-152019-04-152018SILVA JÚNIOR, O. de M. et al. Comparison of the efficacy of losartan, hydrocortisone and acetylsalicylic acid (ASA) in preventing the development of fibrous scar tissue in skeletal muscle. Revista Brasileira de Medicina do Esporte, São Paulo, v. 24, n. 6, p. 418-421, nov./dez. 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-86922018000600418&lng=en&nrm=iso>. Acesso em: 25 fev. 2019.15178692http://www.repositorio.ufop.br/handle/123456789/11009Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3 mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of 0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups. There were no significant differences among the other groups. Conclusion: The healing of striated skeletal muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study.en-USabertoRegenerationTransforming growth factor betaSatellite cellsStriatedComparison of the efficacy of losartan, hydrocortisone and acetylsalicylic acid (ASA) in preventing the development of fibrous scar tissue in skeletal muscle.Comparação da eficácia de losartana, hidrocortisona e ácido acetilsalicílico (AAS) na prevenção do desenvolvimento de tecido cicatricial fibroso nos músculos esqueléticos.Artigo publicado em periodicoTodo o conteúdo do periódico Revista Brasileira de Medicina do Esporte, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Revista Brasileira de Medicina do Esporte <http://www.scielo.br/scielo.php?script=sci_serial&pid=1517-8692&lng=en&nrm=iso>. Acesso em: 19 jan. 2017.