Câmara, Diógenes VadimLemos, Virgínia SoaresSantos, Marcelo Henrique dosNagem, Tanus JorgeCôrtes, Steyner de França2012-05-222012-05-222010CÂMARA, D. V. et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine, v. 17, n. 8-9, p. 690-692, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S094471130900333X>. Acesso em: 22 maio 2012.09447113http://www.repositorio.ufop.br/handle/123456789/762Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.en-USXanthoneProtein kinase CResistance arteryVasodilatationArtigo publicado em periodicoO Periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3490231006877.