Araújo, Márcio Sobreira SilvaAndrade, Renata Aline deVianna, Leonardo RochaMayrink, WilsonReis, Alexandre BarbosaAvelar, Renato SathlerCarvalho, Andréa Teixeira deAndrade, Mariléia ChavesMelo, Maria NormaMartins Filho, Olindo Assis2012-07-052012-07-052008ARAÚJO, M. S. S. et al. Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis. Vaccine, v. 26, n.18, p. 2211-2224, abr. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0264410X08002351>. Acesso em: 05 jul. 2012.0264410Xhttp://www.repositorio.ufop.br/handle/123456789/986Phenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement of monocytes, Leishmune ® induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4 + T-cells with transient activation of CD8 + T-cell, besides decreased frequency of B-cell expressingen-USCanine visceral leishmaniasisLeishvaccineLeishmuneLymphocyte phenotypesDespite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis.Artigo publicado em periodicoO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291401473802.