Machado Júnior, Pedro AlvesSouza, Ana Beatriz Farias deCastro, Thalles de FreitasPerucci, Luiza OliveiraSilva, André Talvani Pedrosa daCangussú, Silvia DantasBezerra, Frank Silva2023-10-272023-10-272022MACHADO JÚNIOR, P. A. et al. The deleterious impact of exposure to different inhaled anesthetics is time dependent. Life Sciences, v. 309, artigo 121004, nov. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0024320522007044?via%3Dihub>. Acesso em: 01 ago. 2023.0024-3205http://www.repositorio.ufop.br/jspui/handle/123456789/17679In this study, the effects of exposure to isoflurane, sevoflurane and desflurane on the oxidative response and inflammation at different times was analyzed in the lungs of adult C57BL/6 mice. 120 animals were divided into 3 groups (n = 40): Isoflurane (ISO), Sevoflurane (SEV) and Desflurane (DES) and exposed to these anesthetics for 1 h (n = 10), 2 h (n = 10) and 3 h (n = 10), at a minimum alveolar concentration (MAC) equal to 1. The control group (CG) (n = 10) was exposed to ambient air. 24 h after the experimental protocol, the animals were euthanized and the bronchoalveolar lavage fluid (BALF), blood and lung tissue samples were collected. In the BALF, animals exposed to isoflurane for 2 h and 3 h showed a greater influx of leukocytes, especially macro- phages compared to the CG. The ISO3h had lower leukocyte counts in the peripheral blood compared to CG, ISO1h and ISO2h. There was an increase in CCL-2 levels in the ISO3h compared to the CG. Superoxide dismutase activity was higher in ISO1h compared to CG. The activity of catalase was higher in the ISO1h and ISO2h compared to the CG. The lipid peroxidation, as well as carbonylated protein were higher in the ISO3h compared to the CG (p < 0.05). Similar results were observed in the exposure of SEV and DES compared to inflammation and redox imbalance in different periods. This study demonstrated that time is a determinant to promote a local and systemic inflammatory response to different inhalational anesthetics in a healthy murine model.en-USrestritoInhalational anestheticsLung inflammationRedox imbalanceMiceArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0024320522007044?via%3Dihubhttps://doi.org/10.1016/j.lfs.2022.121004