Corrêa, Paulo Roberto CeridóreoPinto, Artur da SilveiraSilva, Grácia Divina de FátimaVieira Filho, Sidney AugustoDuarte, Lucienir PainsOgatta, Sueli Fumie Yamada2014-11-142014-11-142011CORRÊA, P. R. et al. In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus. Acta Scientiarum. Biological Sciences, v. 33, n. 4, p. 437-443, 2011. Disponível em: <http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6482>. Acesso em: 20 ago. 2014.1807-863Xhttp://www.repositorio.ufop.br/handle/123456789/3865The effect of 2-pyridinecarboxylic acid (picolinic acid) on trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus was determined in this study. Picolinic acid, at 50 g mL-1, inhibited epimastigote growth by 99% after 12 days incubation. In addition, trypomastigote motility decreased by 50% after 6h and completely after 24h in the presence of 50 g mL-1 picolinic acid. The 50% cytotoxic concentration on HEp-2 cell line was 275 g mL-1 after 4 days incubation. Altogether, these results indicate higher toxicity against trypanosomes. The inhibitory effect of picolinic acid on epimastigote growth can be partially reversed by nicotinic acid and L tryptophan, suggesting a competitive inhibition. Furthermore, two anti-Trypanosoma (Schizotrypanum) cruzi drugs were also evaluated with regard to bat trypanosome growth. Benznidazole, at 50 g mL-1, inhibited epimastigote growth by 90% after 12 days incubation. Nifurtimox, at the same concentration, caused 96% growth inhibition after four days incubation. Corroborating a previous study, bat trypanosomes are a good model for screening new trypanocidal compounds. Moreover, they can be used to study many biological processes common to human pathogenic trypanosomatids.en-USBat trypanosomeSchizotrypanumAntimicrobial activityArtigo publicado em periodicoO periódico Acta Scientiarum. Biological Sciences permite o depósito da versão pós-print de um artigo. Permite remixagem, adaptação e nova criação a partir da obra para fins não comerciais desde que seja atribuído o crédito ao autor (CC BY-NC). Fonte: Diadorim <https://diadorim.ibict.br/handle/1/158>. Acesso em: 09 mar. 2020.http://dx.doi.org/10.4025/actascibiolsci.v33i4.6482