Oliveira, Lucas MartinsSiqueira, Fallon dos SantosSilva, Michelle T.Machado, José Vaz CardosoCordeiro, Cleydson FinottiDiniz, Lívia de FigueiredoCampos, Marli Matiko Anraku deFranco, Lucas LopardiSouza, Thiago Belarmino deHawkes, Jamie AnthonyCarvalho, Diogo Teixeira2023-10-182023-10-182023OLIVEIRA, L. M. et al. Synthesis and antimicrobial activity of molecular hybrids based on eugenol and chloramphenicol pharmacophores. Folia Microbiologica, abr. 2023. Disponível em: <https://link.springer.com/article/10.1007/s12223-023-01057-9>. Acesso em: 01 ago. 2023.1874-9356http://www.repositorio.ufop.br/jspui/handle/123456789/17599In the constant search for new pharmacological compounds, molecular hybridisation is a well-known technique whereby two or more known pharmacophoric subunits are combined to create a new “hybrid” compound. This hybrid is expected to maintain the characteristics of the original compounds whilst demonstrating improvements to their pharmacological action. Accordingly, we report here a series of molecular hybrid compounds based upon eugenol and chloramphenicol pharmacophores. The hybrid compounds were screened for their in vitro antimicrobial potential against Gram-negative and Gram-positive bacteria and also rapidly growing mycobacteria (RGM). The results highlight that the antimicrobial profiles of the hybrid compounds improve in a very clear fashion when moving through the series. The most prominent results were found when comparing the activity of the hybrid compounds against some of the multidrug-resistant clinical isolates of Pseudomonas aeruginosa, methicillin-resistant clinical isolates of Staphylococcus aureus (MRSA) and clinical isolates of rapidly growing mycobacteria.en-USrestritoHybridisationRapidly growing mycobacteriaArtigo publicado em periodicohttps://link.springer.com/article/10.1007/s12223-023-01057-9https://doi.org/10.1007/s12223-023-01057-9