Araujo, Wagner Wlysses Rodrigues deTeixeira, Fernanda de SáSilva, Glenda Nicioli daSalvadori, Daisy Maria FáveroSalvadori, Maria Cecília Barbosa da SilveiraBrown, I. G.2016-07-222016-07-222016ARAUJO, W. W. R. de, et al. Cell growth on 3D microstructured surfaces. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, v. 63, p. 686-689, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0928493116301989>. Acesso em: 16 jun. 2016.0928-4931http://www.repositorio.ufop.br/handle/123456789/6587Chinese Hamster Ovary (CHO) cell cultures were grown on surfaces lithographed with periodic 3D hexagonal microcavity array morphology. The range of microcavity size (inscribed circle diameter) was from 12 μm to 560 μm. CHO cells were grown also on flat surfaces. The characterization was performed with respect to cell growth density (number of nuclei per unit area) by fluorescence opticalmicroscopy and evaluated by correlation function analysis. We found that optimum microcavity radius was 80 μm, concerning to the maximum cell growth density, being even greater than the growth density on a flat (unstructured) substrate of the same material. This finding can be important for optimization of biotechnological processes and devices.en-USabertoBiomaterialsSurface patterningCell aggregationOptical microscopyArtigo publicado em periodicoO periódico Materials Science and Engineering: C concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3894170945574.https://doi.org/10.1016/j.msec.2016.03.026