Leal, Gleisiane Gomes de AlmeidaRoatt, Bruno MendesSoares, Rodrigo Dian de Oliveira AguiarCarneiro, Cláudia MartinsGiunchetti, Rodolfo CordeiroCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisFrancisco, Amanda FortesCardoso, Jamille Mirelle de OliveiraMathias, Fernando Augusto SiqueiraOliveira, Rodrigo Corrêa deCarneiro, MariângelaVital, Wendel CouraReis, Alexandre Barbosa2016-01-152016-01-152014LEAL, G. G. de A. et al. Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Veterinary Parasitology, v. 205, p. 472-482, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304401714004762>. Acesso em: 15 out. 2015.0304-4017http://www.repositorio.ufop.br/handle/123456789/6076Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukinen-USImmunophenotypingCytokinesCanine visceral leishmaniasisArtigo publicado em periodicoO periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732990764611.https://doi.org/10.1016/j.vetpar.2014.08.022