Sousa, Luciana Pereira deGomes, Flávia Lima RibeiroAlmeida, Roberto Farina deSouza, Tadeu Mello eWerneck, Guilherme LoureiroSouza, Diogo OnofreRibeiro, Cláudio Tadeu Daniel2023-05-112023-05-112021SOUZA, L. P. de et al. Immune system challenge improves recognition memory and reverses malaria‐induced cognitive impairment in mice. Scientific Reports, v. 11, artigo 14857, 2021. Disponível em: <https://www.nature.com/articles/s41598-021-94167-8>. Acesso em: 11 out. 2022.2045-2322http://www.repositorio.ufop.br/jspui/handle/123456789/16553The immune system plays a role in the maintenance of healthy neurocognitive function. Diferent patterns of immune response triggered by distinct stimuli may afect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the efect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specifc combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our fndings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the efects of ageing.en-USabertoArtigo publicado em periodicoThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Fonte: o PDF do artigo.https://doi.org/10.1038/s41598-021-94167-8