Guarda, Vera Lúcia de MirandaPerrissin, MoniqueThomasson, FrançoisXimenes, Eulália Camelo Pessoa de AzevedoGaldino, Suely LinsPitta, Ivan da RochaLuu-Duc, CuongBarbe, Jacques2017-10-112017-10-112003GUARDA, V. L. de M. et al. Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones. European Journal of Medicinal Chemistry, Paris, v. 38, p. 769-793, 2003. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0223523403001272>. Aesso em: 20 jan. 2017.0223-5234http://www.repositorio.ufop.br/handle/123456789/8935Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.en-USrestrito1,4-BenzothiazinesAntibacterialsArtigo publicado em periodicohttp://www.sciencedirect.com/science/article/pii/S0223523403001272https://doi.org/10.1016/S0223-5234(03)00127-2