Brito, Larissa FroedeGontijo, Douglas da CostaToledo, Renata Celi LopesBarcelos, Rafael MazioliOliveira, Alaíde Braga deBrandão, Geraldo CélioSousa, Lirlândia Pires deRibeiro, Sônia Machado RochaLeite, João Paulo VianaFietto, Luciano GomesQueiroz, José Humberto de2020-05-182020-05-182019BRITO, L. F. et al. Mangifera indica leaves extract and mangiferin modulate CB1 and PPARγ receptors and others markers associated with obesity. Journal of Functional Foods, v. 56, p. 74-83, maio 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1756464619301227>. Acesso em: 10 fev. 2020.1756-4646http://www.repositorio.ufop.br/handle/123456789/12212This study aimed phytochemical characterization (UPLC-DAD-MS/MS) of ethanolic extract of the leaves from Mangifera indica (EMI) and Mangiferin (MAN), analysis of the cytotoxic (MTT) and anti-inflammatory potential (expression of TNF-α) of EMI and MAN in vitro. In addition, was evaluate the effect on the mRNA expression of genes (CB1, PPARγ, adiponectin, resistin and leptin) associated with adipogenesis in adipose tissue of rats fed a cafeteria diet. Thus, wistar rats were treated by gavage with EMI and MAN for several days (according to the post and co-treatments). The adipose tissue was weighed and checked the expression of different markers by RT-PCR. The presence of MAN as major compound in EMI was verified. Both EMI and MAN were not cytotoxic, with lower EMI expression of TNF-α. Furthermore, EMI and MAN had proadipogenic action on post-treatment, while in the co-treatment, EMI attenuated the effect of adipogenesis and MAN increased the adipogenic process.en-USrestritoAdipogenesisResistinLeptinArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S1756464619301227https://doi.org/10.1016/j.jff.2019.03.003