Galvão, Márcio Antônio MoreiraDumler, J. StephenMafra, Cláudio LísiasCalic, Simone BergerChamone, Chequer BuffeCesarino Filho, GraccoOlano, Juan PabloWalker, David Hughes2014-11-122014-11-122003GALVÃO, M. A. M. et al. Fatal spotted fever rickettsiosis, Minas Gerais, Brazil. Emerging Infectious Diseases, Atlanta, v. 9, n.11, p. 1402-1405, 2003. Disponível em: <https://wwwnc.cdc.gov/eid/article/9/11/03-0193_article>. Acesso em: 08 set. 2014.1080-6059http://www.repositorio.ufop.br/handle/123456789/3842The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.en-USArtigo publicado em periodicoEmerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, all materials published in Emerging Infectious Diseases are in the public domain and can be used without permission. Fonte: Emerging Infectious Diseases <http://wwwnc.cdc.gov/eid/page/copyright-and-disclaimers>. Acesso em: 04 set. 2014.https://dx.doi.org/10.3201/eid0911.030193