Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats.
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2023
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Aims: In rats, stress-induced hyperthermia caused by social interaction depends on brown adipose tissue (BAT)
thermogenesis and peripheral vasoconstriction. However, the peripheral mechanisms responsible for regulating
the level of hyperthermia during social stress are still unknown. The transient receptor potential vanilloid 1
(TRPV1) subfamily, expressed in sensory and visceral neurons, can serve as a thermoreceptor. Here, we tested the
hypothesis that the abdominal TRPV1 is essential in regulating stress-induced hyperthermia during social stress.
Main methods: Male Wistar rats received an intraperitoneal injection of Resiniferatoxin (RTX) - an ultra-potent
capsaicin analog, (i.e., to desensitize the TRPV1 channels) or vehicle. Seven days later, we evaluated the effects of abdominal TRPV1 channels desensitization on core body temperature (CBT), brown adipose tissue (BAT)
temperature, tail skin temperature, and heart rate (HR) of rats subjected to a social stress protocol.
Key findings: We found abdominal TRPV1 desensitization increased CBT and BAT temperature but did not change
tail skin temperature and HR during rest. However, under social stress, we found that abdominal TRPV1
desensitization heightened the increase in CBT and BAT caused by stress. Also, it abolished the increase in tail
skin temperature that occurs during and after social stress. TRPV1 desensitization also delayed the HR recovery
after the exposure to the social stress.
Significance: These results show that abdominal TRPV1 channels desensitization heightens stress-induced hyperthermia, causing heat dissipation during and after social stress, enabling optimal thermal control during social encounters.
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Resiniferatoxin, Social stress, Stress-induced hyperthermia
Citação
REIS, T. O. et al. Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats. Autonomic Neuroscience-basic & Clinical, v. 246, artigo 103073, maio 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1566070223000024?via%3Dihub>. Acesso em: 01 ago. 2023.