New aspects of the glucose activation of the H-ATPase in the yeast Saccharomyces cerevisae.
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Data
2001
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Resumo
The glucose-induced activation of plasma membrane ATPase from
Saccharomyces cerevisiae was first described by Serrano in 1983. Many aspects
of this signal transduction pathway are still obscure. In this paper, evidence is
presented for the involvement of Snf3p as the glucose sensor related to this
activation process. It is shown that, in addition to glucose detection by Snf3p,
sugar transport is also necessary for activation of the ATPase. The participation
of the G protein, Gpa2p, in transducing the internal signal (phosphorylated
sugars) is also demonstrated. Moreover, the involvement of protein kinase C in
the regulation of ATPase activity is confirmed. Finally, a model pathway is
presented for sensing and transmission of the glucose activation signal of the
yeast HM-ATPase.
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Signal transduction, Nutrient signalling
Citação
BRANDAO, R. L.; SOUZA, M. A. A.; TRÓPIA, M. J. M. New aspects of the glucose activation of the H-ATPase in the yeast Saccharomyces cerevisae. Microbiology, Inglaterra, v. 147, n.10, p. 2849-2855, 2001. Disponível em: <http://mic.microbiologyresearch.org/content/journal/micro/10.1099/00221287-147-10-2849#tab2>. Acesso em: 10 jan. 2017.