Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material.
dc.contributor.author | Santos, Stefânia Sales de Oliveira | |
dc.contributor.author | Sinisterra Millán, Ruben Dario | |
dc.contributor.author | Speziali, Marcelo Gomes | |
dc.date.accessioned | 2020-06-16T16:09:03Z | |
dc.date.available | 2020-06-16T16:09:03Z | |
dc.date.issued | 2020 | |
dc.description.abstract | This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems. | pt_BR |
dc.identifier.citation | SANTOS, S. S. O.; MILLÁN, R. D. S.; SPEZIALI, M. G. Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material. European Polymer Journal, v. 124, n. 109490, fev. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014305719320543>. Acesso em: 10 fev. 2020. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.eurpolymj.2020.109490 | pt_BR |
dc.identifier.issn | 0014-3057 | |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/12353 | |
dc.identifier.uri2 | https://www.sciencedirect.com/science/article/pii/S0014305719320543 | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.rights | restrito | pt_BR |
dc.subject | Weibull kinetic model | pt_BR |
dc.subject | Korsmeyer – peppas kinetic model | pt_BR |
dc.subject | pH-dependent | pt_BR |
dc.subject | Silanization | pt_BR |
dc.subject | Desorption | pt_BR |
dc.title | Versatile grafted microcrystalline cellulose with ionic liquid as new losartan-controlled release material. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
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