Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.
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2017
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Resumo
Proline-rich oligopeptides from Bothrops
jararaca (Bj-PROs) produce potent and long-lasting antihypertensive
effect through mechanisms that go beyond
ACE inhibition. In this study we evaluated the renal function
parameters of spontaneously hypertensive rats (SHR)
injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/
kg) found in the CNP-precursor of the snake. At 71 and
710 nmol/kg, Bj-PROs increased urinary flow rate (18.1–
43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated
sodium excretion (68.1 and 40.9%, respectively) and Bj-
PRO-5a also increased urinary sodium/creatinine ratio
(56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal
function. All doses of Bj-PROs reduced blood pressure
(Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce
blood pressure and improve renal functi
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Blood pressure, Heart rate, Hypertension, Prolinerich oligopeptides, Renal function
Citação
XAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <https://link.springer.com/article/10.1007/s10989-017-9575-7>. Acesso em: 15 set. 2017.