Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice.
Nenhuma Miniatura Disponível
Data
2010
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Ageing is associated with several alterations in the immune system. Our aim
in this study was to compare the development of immunity to Schistosoma mansoni
infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main
organ to evaluate pathological alterations and immune responses. In the acute
phase, young mice had large liver granulomas with fibrosis and inflammatory
cells. Chronic phase in young animals was associated with immunomodulation
of granulomas that became reduced in size and cellular infiltrate. On the other
hand, aged animals presented granulomas of smaller sizes already in the acute
phase. Chronic infection in these mice was followed by no alteration in any of
the inflammatory parameters in the liver. In concert with this finding, there
was an increase in activated CD4+ T, CD19+ B and NK liver cells in young
mice after infection whereas old mice had already higher frequencies of activated
B, NK and CD4+ T liver cells and infection does not change these frequencies.
After infection, liver production of inflammatory and regulatory
cytokines such as IFN-c, IL-4 and IL-10 increased in young but not in old
mice that had high levels of IL-4 and IL-10 regardless of their infection status.
Our data suggest that the unspecific activation status of the immune system
in aged mice impairs inflammatory as well as regulatory immune responses to
S. mansoni infection in the liver, where major pathological alterations and
immunity are at stage. This poor immune reactivity may have a beneficial
impact on disease development.
Descrição
Palavras-chave
Citação
FARIA, E. S. et al. Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Scandinavian Journal of Immunology, v. 71, p.240-248, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract>. Acesso em: 10 jan. 2017.