Leishmania chagasi : effect of the iron deficiency on the infection in BALB/c mice.
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2011
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Resumo
Iron deficiency and visceral leishmaniasis are serious problems of public health. The aim of this study was
to evaluate the effect of iron deficiency, induced by the iron chelator desferrioxamine, on the course of
the infection by Leishmania chagasi in BALB/c mice. Our data show that the iron chelator caused significant
reduction in hemoglobin concentration of treated mice and reduction in parasite load in spleen and
liver. Significant differences were not observed in the production of IFN-gamma and IL-4 among the
experimental groups. In conclusion, the data reported in this paper suggest that iron deficiency may favor
the host. If there is not enough iron available to the parasite, its multiplication may be reduced and infection
attenuated.
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Visceral leishmaniasis, Hemoglobin
Citação
MALAFAIA, G. et al. Leishmania chagasi: effect of the iron deficiency on the infection in BALB/c mice. Experimental Parasitology, v. 127, p. 719-723, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0014489410003516>. Acesso em: 20 jan. 2017.