Anti-inflammatory, antimicrobial, antioxidant and photoprotective investigation of red propolis extract as sunscreen formulation in polawax cream.

dc.contributor.authorValverde, Thalita Marcolan
dc.contributor.authorSoares, Bruna Nayane Gonçalves de Souza
dc.contributor.authorNascimento, Andréa Mendes do
dc.contributor.authorAndrade, Ângela Leão
dc.contributor.authorSousa, Lucas Resende Dutra
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorSantos, Vagner Rodrigues
dc.contributor.authorSeibert, Janaína Brandão
dc.contributor.authorAlmeida, Tatiane Cristine Silva de
dc.contributor.authorRodrigues, Caio Fabrini
dc.contributor.authorOliveira, Samantha Roberta Machado de
dc.contributor.authorMartins, Flaviano dos Santos
dc.contributor.authorFerreira Júnior, Jeronimo Geraldo
dc.contributor.authorSantos, Viviane Martins Rebello dos
dc.date.accessioned2023-12-14T19:17:17Z
dc.date.available2023-12-14T19:17:17Z
dc.date.issued2023pt_BR
dc.description.abstractMany activities have been described for propolis, including, antiviral, antibacterial, antifungal, anti-inflammatory, immunoregulatory, antioxidant and wound healing properties. Recently, propolis has been highlighted due to its potential application in the pharmaceutical and cosmetic industries, motivating a better understanding of its antioxidant and anti-inflammatory activities. Propolis and its main polyphenolic compounds presented high antioxidant activity, and effectiveness as broad spectrum UVB and UVA photoprotection sunscreens. Through a qualitative phytochemical screening, the ethanolic red propolis extracts (EEPV) (70% at room temperature and 70% at a hot temperature) presented a positive result for flavonoids and terpenoids. It presented an antioxidant activity for reducing 50% of DPPH of 17 and 12 µg/mL for extraction at room temperature and at a hot temperature, respectively. The UPLC-QTOF-MS/MS analysis allowed the annotation of 40 substances for EEPV-Heated and 42 substances for EEPV-Room Temperature. The IC50 results of the ABTS scavenging activity was 4.7 µg/mL for both extractions, at room temperature and at a hot temperature. Additionally, we also evaluated the cytotoxic profile of propolis extracts against macrophage (RAW 264.7 cells) and keratinocytes (HaCaT cells), which showed non-cytotoxic doses in cell viability assays even after a long period of exposure. In addition, propolis extracts showed antibacterial activity for Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), demonstrating potential biological activity for the creation of formulations aimed at disease control and prevention.pt_BR
dc.identifier.citationVALVERDE, T. M. et al. Anti-inflammatory, antimicrobial, antioxidant and photoprotective investigation of red propolis extract as sunscreen formulation in polawax cream. International Journal of Molecular Sciences, v. 24, n. 6, artigo 5112, 2023. Disponível em: <https://www.mdpi.com/1422-0067/24/6/5112>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms24065112pt_BR
dc.identifier.issn1422-0067
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17935
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.pt_BR
dc.subjectRed propolispt_BR
dc.subjectPhotoprotectivept_BR
dc.subjectAntioxidantpt_BR
dc.subjectEthanolic extractspt_BR
dc.subjectAnti-inflammatorypt_BR
dc.titleAnti-inflammatory, antimicrobial, antioxidant and photoprotective investigation of red propolis extract as sunscreen formulation in polawax cream.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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