Epigenetic regulation of the N-terminal truncated isoform of matrix metalloproteinase-2 (NTT-MMP-2) and Its presence in renal and cardiac diseases.
dc.contributor.author | Cruz, Juliana de Oliveira | |
dc.contributor.author | Silva, Alessandra Oliveira | |
dc.contributor.author | Ribeiro, Jessyca Milene | |
dc.contributor.author | Luizon, Marcelo Rizzatti | |
dc.contributor.author | Ceron, Carla Speroni | |
dc.date.accessioned | 2023-03-24T18:19:36Z | |
dc.date.available | 2023-03-24T18:19:36Z | |
dc.date.issued | 2021 | pt_BR |
dc.description.abstract | Several clinical and experimental studies have documented a compelling and critical role for the full-length matrix metalloproteinase-2 (FL-MMP-2) in ischemic renal injury, progressive renal fibrosis, and diabetic nephropathy. A novel N-terminal truncated isoform of MMP-2 (NTT-MMP-2) was recently discovered, which is induced by hypoxia and oxidative stress by the activation of a latent promoter located in the first intron of the MMP2 gene. This NTT-MMP-2 isoform is enzymatically active but remains intracellular in or near the mitochondria. In this perspective article, we first present the findings about the discovery of the NTT-MMP-2 isoform, and its functional and structural differences as compared with the FL-MMP-2 isoform. Based on publicly available epigenomics data from the Encyclopedia of DNA Elements (ENCODE) project, we provide insights into the epigenetic regulation of the latent promoter located in the first intron of the MMP2 gene, which support the activation of the NTT-MMP-2 isoform. We then focus on its functional assessment by covering the alterations found in the kidney of transgenic mice expressing the NTT-MMP-2 isoform. Next, we highlight recent findings regarding the presence of the NTT-MMP-2 isoform in renal dysfunction, in kidney and cardiac diseases, including damage observed in aging, acute ischemia-reperfusion injury (IRI), chronic kidney disease, diabetic nephropathy, and human renal transplants with delayed graft function. Finally, we briefly discuss how our insights may guide further experimental and clinical studies that are needed to elucidate the underlying mechanisms and the role of the NTT-MMP-2 isoform in renal dysfunction, which may help to establish it as a potential therapeutic target in kidney diseases. | pt_BR |
dc.identifier.citation | CRUZ, J. de O. et al. Epigenetic regulation of the N-terminal truncated isoform of matrix metalloproteinase-2 (NTT-MMP-2) and Its presence in renal and cardiac diseases. Frontiers in genetics, v. 12, artigo 637148, fev. 2021. Disponível em: <https://www.frontiersin.org/articles/10.3389/fgene.2021.637148/full>. Acesso em: 11 out. 2022. | pt_BR |
dc.identifier.doi | https://doi.org/10.3389/fgene.2021.637148 | pt_BR |
dc.identifier.issn | 0166-4328 | |
dc.identifier.uri | http://www.repositorio.ufop.br/jspui/handle/123456789/16425 | |
dc.language.iso | en_US | pt_BR |
dc.rights | aberto | pt_BR |
dc.rights.license | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o PDF do artigo. | pt_BR |
dc.subject | Mitochondria | pt_BR |
dc.subject | Epigenomics | pt_BR |
dc.subject | Acute kidney injury | pt_BR |
dc.subject | Alternative promoter | pt_BR |
dc.subject | Chronic kidney disease | pt_BR |
dc.title | Epigenetic regulation of the N-terminal truncated isoform of matrix metalloproteinase-2 (NTT-MMP-2) and Its presence in renal and cardiac diseases. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
Arquivos
Pacote Original
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- ARTIGO_EpigeneticRegutationNTerminal.pdf
- Tamanho:
- 1.26 MB
- Formato:
- Adobe Portable Document Format
- Descrição:
Licença do Pacote
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: