Vaccination with formulation of nanoparticles loaded with Leishmania amazonensis antigens confers protection against experimental visceral leishmaniasis in hamster.
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2023
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Visceral leishmaniasis (VL) is a fatal disease caused by the protozoa Leishmania infantum for
which dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) could be
an important tool in the control of human and CVL by reducing the infection pressure of L. infantum.
Despite the CVL vaccine available on the market, the Brazilian Ministry of Health did not implement
the use of it in their control programs. In this sense, there is an urgent need to develop more
efficient vaccines. In this study, the association between two polymeric nanoformulations, (poly (D,
L-lactic) acid (PLA) polymer) loading Leishmania amazonensis antigens, was evaluated as a potential
immunobiological agent against VL using golden hamsters as an experimental model. The results
indicated that no significant adverse reactions were observed in animals vaccinated with LAPSmP.
LAPSmP presented similar levels of total anti-Leishmania IgG as compared to LAPSmG. The LAPSmP
and LAPSmG groups showed an intense reduction in liver and spleen parasitic load by qPCR. The
LAPSmP and LAPSmG vaccines showed exceptional results, indicating that they may be promising
candidates as a VL vaccine.
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Nanotechnology, Vaccine
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CABRERA GONZÁLEZ, M. A. et al. Vaccination with formulation of nanoparticles loaded with Leishmania amazonensis antigens confers protection against experimental visceral leishmaniasis in hamster. Vaccines, v. 11, n. 1, artigo 111, 2023. Disponível em: <https://www.mdpi.com/2076-393X/11/1/111>. Acesso em: 01 ago. 2023.